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Preprint CASE REPORT | doi:10.20944/preprints202301.0379.v1

Combined Invasive Peripheral Nerve Stimulation in the Management of Chronic Post-Intracranial Disorder Headache. A Case Report.

Athanasia Alexoudi, Eustathios Vlahakis, Stamatios Banos, Konstantinos Oikonomou, Panayiotis Patrikelis, Anastasia Verentzioti, Maria Stefanatou, Stylianos Gatzonis, Stefanos Korfias, Damianos Sakas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Combined Peripheral Nerve Stimulation; occipital nerve stimulation; secondary headache disor-ders; chronic post-intracranial disorder headache and case report

Online: 23 January 2023 (00:57:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1875.v1

Neuromodulation Techniques for Headache Management

Noora Reffat, Carolina Pusec, Scott J Price, Mayank Gupta, Philippe Mavrocordatos, Alaa Abd Elsayed

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: headache; migraine; chronic cluster headache; neuromodulation; pain management

Online: 29 November 2023 (10:39:12 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202011.0668.v1

Case Report - Unstable Angina, Coronary Artery Disease, and Cannabis

Brian Entler, Brian Shaffer, Garrison Davis, Marc Incitti, Brian Piper

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: marijuana; medicinal cannabis (MC); chronic pain (CP); cannabidiol (CBD); tetrahydrocannabinol (THC)

Online: 26 November 2020 (11:22:28 CET)

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Rationale:First discovered in 1990, the endocannabinoid system (ECS) was initially shown to have an intimate relationship with central areas of the nervous system associated with pain, reward, and motivation. Recently, however, the ECS has been extensively implicated in the cardiovascular system with contractility, heart rate, blood pressure, and vasodilation. Emerging data demonstrates modulation of the ECS plays an essential role in cardio metabolic risk, atherosclerosis, and can even limit damage to cardiomyocytes during ischemic events.Patient Concerns:This case describes a 63-year-old male who presented to a primary care physician for a medical cannabis (MC) consult due to unstable angina (UA) not relieved by morphine or cardiac medications; having failed all first- and second-line poly-pharmaceutical therapies. The patient reported frequent, unprovoked, angina and exertional dyspnea.Diagnosis:Having a complex cardiac history, the patient first presented 22 years ago after a suspected myocardial infarction (MI). He re-presented in 2010 and underwent stent placement at that time for inoperable triple-vessel coronary artery disease (CAD) which was identified via percutaneous transluminal coronary angioplasty. UA developed on follow up and, despite medical management over the past 6 years, his UA became progressively debilitating.Interventions and Outcomes:In conjunction with his standard cardiac care, patient had a gradual lessening of UA related pain, including frequency and character, after using an edible form of medical cannabis (MC) (1:1 CBD:THC). Following continued treatment, he ceased long term morphine treatment and describes the pain as no longer crippling. As demonstrated by his exercise tolerance tests, the patient experienced an improved functional capacity and reported an increase in his daily functioning, and overall activity.Lessons:This case uniquely highlights MC in possibly reducing the character, quality, and frequency of UA; while concordantly improving functional cardiac capacity in a patient with CAD. Additional case reports are necessary to verify this.

Preprint REVIEW | doi:10.20944/preprints202309.2129.v1

Refractory Immune Thrombocytopenia or Myelodysplastic Syndrome Presenting with Isolated Thrombocytopenia? A Review of Literature and a Case Report

Riccardo Tomasello, Claudia Cammarata, Marta Mattana, Manuela Giuseppa Ingrascì, Giulio Giordano, Alessandro Lucchesi, Waleed Ghanima, Sergio Mario Siragusa, Mariasanta Napolitano

Subject: Medicine And Pharmacology, Hematology Keywords: Immune thrombocytopenia; chronic ITP; myelodysplastic syndrome; chronic myelomonocytic leukemia; refractory thrombocytopenia

Online: 30 September 2023 (07:14:13 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202310.0937.v1

Whole-Body Cryostimulation in Functional Neurological Disorders: A Case-Report

Federica Verme, Jacopo Maria Fontana, Paolo Piterà, Angelo Alito, Silvia Saffioti, Gabriele Baccalaro, Giuliano Zebellin, Paolo Capodaglio

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic pain; conversion disorder; functional neurological disorders; rehabilitation; whole-body cryostimulation

Online: 16 October 2023 (09:04:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1839.v1

Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies

Konstantinos Manganas, Aikaterini Xydaki, Angeliki Kotsiafti, Olympia Papakonstantinou, Sophia Delicou

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: extramedullary hematopoiesis; chronic hemolytic anemia; thalassemia; blood transfusions; radiation therapy; surgical decompression; hydroxyurea therapy

Online: 25 December 2023 (08:15:21 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0560.v1

Effects of Whole-Body Cryostimulation on pain management and disease activity in active Rheumatic Polymyalgia: a Case-Report

Federica Verme, Alessandra Scarpa, Giorgia Varallo, Paolo Piterà, Paolo Capodaglio, Jacopo Maria Fontana

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Polymyalgia Rheumatica; Whole-Body Cryostimulation; Chronic Pain; Disease Activity; Rehabilitation

Online: 9 May 2023 (04:17:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2091.v1

Assessing Functional Capacity in ME/CFS: A Patient Informed Questionnaire

Kristian Sommerfelt, Trude Schei, Katharine A Seton, Simon R Carding

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ME/CFS; chronic fatigue syndrome; functional capacity; post exertional malaise; questionnaire; survey

Online: 29 September 2023 (09:21:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0296.v1

Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Literature Review

Richard I. Horowitz, Phyllis R. Freeman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dapsone; disulfiram; chronic Lyme disease; Post-Treatment Lyme Disease Syndrome; babesia; bartonella; persisters; biofilms.

Online: 29 April 2022 (10:12:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0059.v1

Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Mariaconsiglia Santantonio, Carmela Riso, Simona Gaudino, Alessio Simonetti, Giuseppe Varcasia, Francesco Schimperna, Bruno Sergi, Eugenio De Corso, Marco Rossi, Jacopo Galli, Marco De Spirito, Giuseppe Maulucci, Giulio Cesare Passali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: olfactory rehabilitation; chronic pain; fMRI

Online: 1 March 2024 (18:18:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0289.v1

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Varvara A. Ryabkova, Natalia Y Gavrilova, Tamara V Fedotkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; post-COVID syndrome; postural orthostatic tachycardia; microcirculation; immune system

Online: 20 September 2022 (03:37:00 CEST)

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A Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology under growing interest now in view of the increasingly recognized post-COVID syndrome as a new entity with similar clinical presentation. We performed the first cross-sectional study of ME/CFS in community population in Russia and then described and compared some clinical and pathophysiological characteristics of ME/CFS and post-COVID syndrome as neuroimmune disorders. Of the cohort of 76 individuals who suggested themselves suffering from ME/CFS 56 subsequently were confirmed as having CFS/ME according to ≥1 of the 4 most commonly used case definition. Of the cohort of 14 individuals with post-COVID-19 syndrome 14 met diagnostic criteria for ME/CFS. The prevalence of clinically expressed and subclinical anxiety and depression in ME / CFS and post-COVID ME/CFS did not differ significantly from that in healthy individuals. Severity of anxiety / depressive symptoms did not correlate with the severity of fatigue neigther in ME / CFS nor in post-COVID ME/CFS, but the positive correlation was found between the severity of fatigue and 20 other symptoms of ME / CFS related to the domains of “post-exertional exhaustion”, “immune dysfunction”, “sleep disturbances”, "dysfunction of the autonomic nervous system", "neurological sensory / motor disorders" and "pain syndromes". Immunological abnormalities were identified in 12/12 patients with ME / CFS according to the results of laboratory testing. The prevalence of postural orthostatic tachycardia assessed by the active standing test was 37.5% in ME / CFS and 75.0% in post-COVID ME/CFS (the latter was higher than in healthy controls, p = 0.02) There was a more pronounced increase in heart rate starting from the 6th minute of the test in post-COVID ME/CFS compared with the control group. Assessment of the functional characteristics of microcirculation by laser doppler flowmetry revealed obvious and very similar changes in ME/CFS and post-COVID ME/CFS compared to the healthy controls. The identified pattern corresponded to the hyperemic form of microcirculation disorders, usually observed in acute inflammatory processes or in deficiency of systemic vasoconstriction influences.

Preprint ARTICLE | doi:10.20944/preprints202311.1228.v1

Varvara Aleksandrovna Ryabkova, Artemiy Vladimirovich Rubinskiy, Valeriy Nikolaevich Marchenko, Vasiliy Ivanovich Trofimov, Leonid Pavlovich Churilov

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; COVID-19; Post-COVID; heart rate variability; autonomic dysfunction

Online: 20 November 2023 (07:51:21 CET)

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Background There is a considerable overlap between clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) . Many of their common symptoms can be linked to dysregulation of the autonomic nervous system (dysautonomia). This study aimed to objectively assess autonomic function in patients with PCC and in patients with ME/CFS whose disease was not related to COVID-19. Methods Synchronous recordings of an electrocardiogram, continuous dynamics of blood pressure in the digital artery using the Penaz method and ultrasound pneumotachography with the spirography function were obtained with spiroarteriocardiorhythmography method in 34 patients diagnosed with ME/CFS, in whom the onset of the disease was not associated with COVID-19, 29 patients meeting PCC definition and 32 healthy controls. Heart rate variability (HRV), systolic and diastolic blood pressure variability (RV), respiration variability were assessed at rest and in tests with fixed respiratory rates. At rest, indicators of baroreflex regulation were additionally determined (baroreflex effectiveness index and baroreflex sensitivity). Results The total power, power of very low frequency, low-frequency and high-frequency of RR interval variability at rest as well as baroreflex effectiveness index in up-ramps of arterial blood pressure and baroreflex sensitivity were significantly lower both in PCC and ME/CFS patients compared to HC. Several diagnostic prediction models for ME/CFS were developed based on HRV parameters. During slow breathing HRV parameters return to normal in PCC, but not in ME/CFS. Correlation analysis revealed a close relationship of HRV, RV parameters and baroreflex sensitivity with fatigue, but not with HADS depressive/anxiety symptoms in ME/CFS and PCC. Conclusion A similar pattern of HRV and baroreflex failure with signs of a pathological acceleration of age-dependant dysautonomia was identified in ME/CFS and PCC. The clinical, diagnostic and therapeutic implications of these findings are discussed, in light of previously described relationship between inflammation, vascular pathology, atherosclerotic cardiovascular disease and autonomic dysfunction.

Preprint ARTICLE | doi:10.20944/preprints201912.0395.v1

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Antonello Sica, Beniamino Casale, Caterina Sagnelli, Armando Calogero, Maria Teresa Di Dato, Alessandro Spada, Marco Rispoli, Mario Santagata, Pietro Buonavolontà, Alfonso Fiorelli, Vincenzo Tammaro, Massimo Ciccozzi, Anna Salzano, Evangelista Sagnelli, Elisabetta Saracco, Dario Tammaro, Alfonso Papa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: physical activity; elderly population; chronic pain; mediastinal lymphomas

Online: 30 December 2019 (09:44:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1554.v1

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

David Mantle, Iain Parry Hargreaves, Joan Carles Domingo, Jesus Castro-Marrero

Subject: Biology And Life Sciences, Life Sciences Keywords: chronic fatigue syndrome; coenzyme Q10; fibromyalgia; Long COVID; mitochondrial dysfunction; myalgic encephalomyelitis; post-viral fatigue syndrome

Online: 24 November 2023 (11:27:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0882.v1

Acute Kidney Disease following Acute Kidney Injury in Children—A Retrospective Observational Cohort Study on Risk Factors and Outcomes

Flavia Chisavu, Lazar Chisavu, Viviana Ivan, Adalbert Schiller, Adelina Mihaescu, Luciana Marc, Ramona Stroescu, Ruxandra Maria Steflea, Mihai Gafencu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acute kidney disease; children; mortality; chronic kidney disease

Online: 15 April 2024 (04:46:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0138.v1

Danggui-Shaoyao-San, a Traditional Chinese Medicine, Relieved Depression and Cognitive Disorder Induced by Chronic Restraint Stress Involved in Regulating Dendritic Spines Remodeling

Kecheng Zhou, Junbin Yin, Huanghui Wu, Wei Hu, Zhen Gao, Fang Li, An'an Wu, Wen Wang, Junping Kou

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Danggui-Shaoyao-San, chronic restraint stress, learning and memory, anxiety/depression, structural plasticity

Online: 31 January 2017 (15:30:41 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202103.0680.v1

Post–Chikungunya Virus Infection Musculoskeletal Disorders: Syndromic Sequelae after an Outbreak

Hisham A. Imad, Wasin Matsee, Sajikapon Kludkleeb, Punyisa Asawapaithulsert, Juthamas Phadungsombat, Emi E. Nakayama, Keita Suzuki, Pornsawan Leaungwutiwong, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Tatsuo Shioda

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Acute febrile illness; Alphavirus; chikungunya virus; post-chikungunya musculoskeletal disorder; post-chikungunya chronic inflammatory rheumatism

Online: 29 March 2021 (10:56:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0220.v1

Service Innovations in Health Care Service Ecosystem: A Case Study

Maria Vincenza Ciasullo, Silvia Cosimato

Subject: Business, Economics And Management, Business And Management Keywords: innovation; service innovation; healthcare; chronic diseases; SD Logic

Online: 30 March 2017 (17:10:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202209.0035.v2

Application of Amniotic Membrane Allografts in Advanced Venous Leg Ulcer: A Case Study and Literature Review

Naomi Lambert, Eric Vinke, Tyler Barrett, Matthew Regulski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic Venous Insufficiency; Venous Leg Ulcer; Dehydrated Amniotic Membrane Allograft

Online: 5 September 2022 (10:57:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1507.v1

Optimizing Flexible Microelectrode Designs for Enhanced Efficacy in Electrical Stimulation Therapy

Lihong Qi, Ying Yu, Zeru Tao, Mujie Liu, Yongwei Jiang, Kai Yao, Yuheng Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Flexible; Serpentine Structure; MEMS; Electrical Stimulation Therapy; Chronic Wound Healing

Online: 27 February 2024 (10:23:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1998.v1

Low Post-treatment Quality of Life and the High Incidence of Pain are Common and Significantly Exacerbated in Depressed Head and Neck Patients Treated with Definitive Accelerated Radiotherapy

Alicja Heyda, Dorota Księżniak-Baran, Andrzej Wygoda, Krzysztof Składowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: definitive accelerated radiotherapy; depression; chronic pain; head and neck cancer; quality of life

Online: 28 September 2023 (10:41:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0735.v1

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)

Derek Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig Hughes, Rachael Hunter, Dominic Trepel, Xia Wang-Steverding

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ME/CFS; myalgic encephalomyelitis; chronic fatigue syndrome; primary care; GP knowledge and understanding

Online: 30 November 2020 (15:44:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0039.v1

Racial Disparities in Post-Acute Home Health Care Referral and Utilization Among Older Adults with Diabetes

Jamie M. Smith, Olga F. Jarrín, Haiqun Lin, Tina Dharamdasani, Jennifer Tsui, Charlotte Thomas-Hawkins

Subject: Public Health And Healthcare, Nursing Keywords: Chronic conditions; diabetes; older adults; race or ethnicity; health care access; home health care; social determinants of health; inequalities or inequities

Online: 1 February 2021 (14:03:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0980.v1

Does the Metabolic Syndrome and Its Components Have Prognostic Significance for Renal and Cardiovascular Outcomes in IgA Nephropathy?

Balázs Sági, Tibor Vas, Botond Csiky, Judit Nagy, Tibor József Kovács

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; IgA nephropathy; Renal function; Metabolic syndrome; Arterial stiffness

Online: 15 April 2024 (14:53:42 CEST)

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Background: Cardiovascular (CV) morbidity and mortality are many times higher in chronic kidney disease (CKD), as well as IgA nephropathy (IgAN), than in the general population. The occurrence of metabolic syndrome (MetS) and metabolic risk factors are independent risk factors for CV disease and renal progression. The study aimed to determine the prognostic role of metabolic profiles in a homogenous group of CKD patients. Methods: One hundred and forty-five IgA nephropathy patients (92 male, 53 female, age 54.7 ± 13 years) with CKD stage 1-4 were investigated and followed for a median of 190 months. The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularization (CV), end-stage renal disease, and renal replacement therapy (renal). Results: Patients with MetS had significantly more endpoint events (16/27 patients vs. 15/98 patients, p = 0.001) compared to the nonMetS group. Of the secondary endpoints (CV or renal separately), the rate of the renal and CV endpoints was significantly higher in the MetS group (p = 0.001 and p = 0.029). The primary endpoint independent predictors of survival were dyslipidemia, eGFR, hemoglobin, urine albuminuria, and diabetes mellitus, as determined by Cox regression analysis. Independent predictors of secondary renal endpoint were dyslipidemia, hemoglobin, urine albumin, and eGFR. Predictors of secondary cardiovascular endpoints were gender, BMI, and diabetes. Kaplan-Meier curves showed significant differences in MetS and non-MetS when examined at the combined endpoints (CV and renal) or at each endpoint separately. The primary endpoint rate increased significantly with the increased number of MetS components (MetS comp. 0 vs. MetS comp. 2+, primary endpoints, p = 0.012). Conclusion: Our results showed that the metabolic profile has a prognostic role not only for renal endpoints but also for CV endpoints in IgAN. BMI, hyperuricemia, hypertension, and diabetes have a predictive value for the prognosis of IgA nephropathy.

Preprint CASE REPORT | doi:10.20944/preprints202306.1128.v1

Myeloid Sarcoma as an Unusual Presentation of Acute and Chronic Myeloid Leukemia: A Case Series

Ugo Giordano, Mateusz Sawicki, Justyna Pilch, Jakub Mizera, Artur Borkowski, Krzysztof Zduniak, Jarosław Dybko

Subject: Medicine And Pharmacology, Hematology Keywords: myeloid sarcoma; acute myeloid leukemia; chronic myeloid leukemia; chloroma; granulocytic sarcoma; case report

Online: 16 June 2023 (07:15:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1286.v1

Bioactive Compounds from Pigmented Corn (Zea mays L.) and Their Effect on Health

Yaír Adonaí Sánchez-Nuño, Martín Zermeño-Ruiz, Olga Deli Vázquez-Paulino, Karla Nuño, Angélica Villarruel López

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: pigmented corn; Zea mays L.; functional foods; nutraceuticals; bioactive compounds; phytochemicals; chronic noncommunicable diseases; antioxidants

Online: 22 February 2024 (15:28:46 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.2264.v1

Chronic Fatigue Syndrome and Multiple Sclerosis have Reduced Craniospinal Compliance and Dilated Pressurized Bridging Cortical Veins: A Hypothesis Illustrated with Two Case Studies

Grant Bateman, Alexander Bateman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chronic fatigue syndrome; myalgic encephalomyelitis; multiple sclerosis; cortical vein; venous pressure

Online: 31 May 2023 (14:31:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1668.v1

Multidisciplinary Approach to Primary Immunodeficiency Due to Defect in Innate Immunity: About a Case

Álvaro Astasio-Picado, Jesus Jurado Palomo, Maria Carmen Zabala Baños

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Chronic-granulomatous disease, NADPH oxidase, human neutrophils, superoxide, immune deficiciency, recurrent infections

Online: 25 September 2023 (13:01:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0283.v1

Concentrations of C-Reative Protein and Leukocytes as Predictors of Adverse Health Factors in the Period of 30 Days Post-Hospital Discharge

Nayara Araújo dos Reis, Rosalina Aparecida Partezani Rodrigues, Darlene Mara dos Santos Tavares, Jack Roberto Silva Fhon, Jair Sindra Virtuoso Júnior

Subject: Medicine And Pharmacology, Hematology Keywords: chronic inflammation; biomarker panels; leukocyte count; C-reactive protein; related syndromes and pathologies; risk assessment; screening programmes; ageing; elderly's health

Online: 25 October 2019 (04:16:43 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1619.v1

A Rare Onset of T Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations

Alessandra Mongia, Francesca Romano, Sara Ciullini Mannurita, Benedetta Peruzzi, Sara Bencini, Daniela Parrini, Laura Fasano, Alessandra Fanelli

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; T lymphoid blastic crisis

Online: 27 March 2024 (06:21:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0005.v2

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog

Francesco Menichetti

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Covid-19; post-COVID syndrome; neuroendocrine disorders; chronic fatigue; brain fog; phospholipids; phospholipid liposome; phosphatidylserine

Online: 15 August 2023 (05:03:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0421.v1

Enhancing Post-Surgical Rehabilitation Outcomes in Patients with Chronic Ankle Instability: Impact of Subtalar Joint Axis Balance Exercises Following Arthroscopic Modified Broström Operation

Ji Myeong Park, Sang Ho Han, Byeong Chae Cho, Se Min Lee, Mal Soon Shin, Jae Ho Yu, Ho Jin Kim, Hyun Dong Noh, Min Suk Cho, Myung Ki Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Anterior talofibular ligament; arthroscopic modified Broström operation; chronic ankle instability; subtalar joint axis balance exercises

Online: 4 January 2024 (14:30:30 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202202.0288.v1

A Case of Focal Segmental Glomerulosclerosis in a Young Girl with a Very Low Birth Weight

Yasuyo Kashiwagi, Kazushi Agata, Gaku Yamanaka, Hisashi Kawashima

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chronic kidney disease; low birth weight; focal segmental glomerulosclerosis; two-hit theory

Online: 23 February 2022 (08:26:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0188.v1

How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS

Luis Nacul, Shennae O'Boyle, Flavio E. Nacul, Kathleen Mudie, Caroline C. Kingdon, Jacqueline M. Cliff, Taane G. Clark, Hazel M. Dockrell, Eliana M. Lacerda

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Chronic Fatigue Syndrome; Chronic Illness; ME/CFS; Management; Research

Online: 17 September 2019 (12:38:57 CEST)

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We propose a framework for the understanding of the pathophysiology and management of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants of health and long-term temporal variation in pathophysiological features and disease phenotype throughout the natural history of the disease. As in other chronic diseases, ME/CFS evolves through different stages, from asymptomatic predisposition, progressing to a prodromal stage, and then to symptomatic disease. Disease incidence depends on genetic makeup and environment factors, the exposure to an insult, or repeated insults, and the nature of the host response. In people who develop ME/CFS, normal homeostatic processes in response to adverse insults may be replaced by aberrant responses leading to dysfunctional states. Thus, the predominantly neuro-immune and autonomic manifestations, underlined by a hyper-metabolic state, that characterise early disease, may be followed by various processes leading to multi-systemic related symptoms. This abnormal metabolic state and the effects of a range of mediators such as products of oxidative and nitrosamine stress, may lead to progressive cell and metabolic dysfunction culminating in a hypometabolic state with low energy production. These processes do not seem to happen uniformly; although a spiralling of progressive inter-related and self-sustaining abnormalities may ensue, reversion to states of milder abnormalities is possible if the host is able to restate responses to improve homeostatic equilibrium. Disease management and research efforts should seek to identify and apply strategies targeted at the different pathophysiological dysfunctions that characterise different disease stages. As disease presentation varies over time, no single case description, set of diagnostic criteria, or molecular feature is currently diagnostic for all patients at all times. While acknowledging its limitations due to the incomplete research evidence, we suggest the proposed framework may improve research design and health care interventions for people with ME/CFS.

Preprint REVIEW | doi:10.20944/preprints202403.0306.v1

Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders

Šojat Dunja, Volarić Mile, Tanja Keškić, Nikola Volarić, Venija Cerovečki, Ljiljana Majnarić Trtica

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: gastrointestinal diseases; chronic diseases; cytokines; gastrointestinal microbiome; inflammation

Online: 6 March 2024 (10:57:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0018.v2

Effects of Excitatory Repetitive Transcranial Magnetic Stimulation of the P3 Point in Chronic Stroke Patients – Case Reports

Ronaldo Luis da Silva, Angela Maria Costa de Souza, Francielly Ferreira Santos, Sueli Toshie Inoue, Johanne Higgins , Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: intraparietal sulcus; stroke; rTMS; Fugl-Meyer Assessment; fast frequency TMS; motricity; sensibility; chronic patients

Online: 17 April 2018 (08:35:18 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202312.0791.v1

Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in ME/CFS Evolving from the Post COVID-19 Syndrome

Klaus Josef Wirth, Matthias Löhn

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Post-COVID Syndrome, Long-COVID; Long-COVID; Precapillary cardiovascular disturbances; Capillary disturbances; ß2AdR dysfunction; Mitochondrial dysfunction; Post-Exertional Malaise; Exercise intolerance

Online: 13 December 2023 (03:40:03 CET)

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID Syndrome (PCS). A fraction of the PCS patients develops the full clinical picture of ME/CFS. New observations in microvessels and blood from patients suffering from PCS have appeared and include microclots and malformed pathological blood cells. Capillary blood flow is impaired not only by pathological blood components but also by prothrombotic changes in the vascular wall, endothelial dysfunction, and expression of adhesion molecules in the capillaries. These disturbances can finally cause a low capillary flow and even capillary stasis. A low cardiac stroke volume due to hypovolemia and the inability of the capacitance vessels to adequately constrict to deliver the necessary cardiac preload generate an unfavorable low precapillary perfusion pressure. Furthermore, a predominance of vasoconstrictor over vasodilator influences exists, in which sympathetic hyperactivity and endothelial dysfunction play a strong role, causing constriction of resistance vessels and of precapillary sphincters which leads to a fall in capillary pressure behind the sphincters. The interaction of these two precapillary cardiovascular mechanisms causing a low capillary perfusion pressure is hemodynamically highly unfavorable in the presence of a primary capillary stasis already caused by the pathological blood components and their interaction with the capillary wall, to severely impair organ perfusion. The detrimental coincidence of the microcirculatory with the precapillary cardiovascular disturbances may constitute the key disturbance of the Post-COVID-19 syndrome and finally lead to ME/CFS in pre-disposed patients because the interaction causes a particular kind of perfusion disturbance - capillary ischemia-reperfusion - which has a high potential of causing mitochondrial dysfunction by inducing sodium- and calcium-overload in skeletal muscles. The latter in turns worsens the vascular situation by the generation of reactive oxygen species to close a vicious cycle from which the patient can hardly escape.

Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0455.v1

Novel Dairy Fermentates Have Differential Effects on Key Immune Responses Associated with Viral Immunity and Inflammation

Dearbhla Finnegan, Monica A Mechoud, Claire Connolly, Jamie A FitzGerald, Tom Beresford, Harsh Mathur, Lorraine Brennan, Paul D. Cotter, Christine Loscher

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Fermentates; functional food; immune boosting; immunomodulation; anti-inflammatory; viral immunity; chronic inflammation

Online: 7 April 2024 (22:43:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0148.v1

Innate and Adaptive Immune Responses in Chronic Hepatitis C Virus and Hepatitis B Virus Infection with High Viral Loads

Yutaka Kishida

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: chronic hepatitis C; chronic hepatitis B; innate immune response; adaptive immune response; cytokine; chemokine

Online: 12 April 2019 (10:59:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0808.v1

Flourishing Among Children and Adolescents with Chronic Pain and Emotional, Developmental, or Behavioral Comorbidities

Madeline Foster, Jessica Emick, Nathan M. Griffith

Subject: Social Sciences, Psychology Keywords: chronic pain; mental health; comorbidities; flourishing

Online: 10 August 2023 (07:31:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1789.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Darren Gopaul, Sachin Soodeen, Odalis Asin-Milan, Clovis Palmer, Patrick Eberechi Akpaka

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 26 July 2023 (10:39:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1557.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Patrick Eberechi Akpaka, Darren Gopaul

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 21 June 2023 (13:10:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1787.v1

Vitamin D deficiency, Chronic kidney disease and Periodontitis

Imaan Ganimusa, Emily Chew, Emily Ming-Chieh Lu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Vitamin D, Chronic kidney disease, periodontitis

Online: 24 January 2024 (16:53:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0343.v1

A Theoretical Model Explaining the Development and Maintenance of Clinical Burnout

Niclas Almén

Subject: Social Sciences, Psychology Keywords: Chronic stress; Recovery; Burnout; Exhaustion; Maintenance

Online: 17 February 2021 (07:45:19 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0177.v1

Incidence and Characteristics of Endophthalmitis after Cataract Surgery in Poland, during 2010-2015

Michal S. Nowak, Andrzej Grzybowski, Katarzyna Michalska-Malecka, Jacek P. Szaflik, Milena Koziol, Wojciech Niemczyk, Iwona Grabska-Liberek

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Cataract surgery, acute endophthalmitis, chronic endophthalmitis

Online: 14 May 2019 (15:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0028.v2

Motivating Diabetic and Hypertensive Patients to Engage in Regular Physical Activity: A Multi-Component Intervention Derived from the Concept of Photovoice

Angela Y. M. Leung, Pui Hing Chau, Isaac S. H. Leung, Michael Tse, Perick Lai Choi Wong, Wai Ming Tam, Doris Y. P. Leung

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: photovoice; chronic illness; physical activity; barriers; facilitator

Online: 2 April 2019 (07:48:28 CEST)

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Aims: A community-based multi-component intervention (increasing awareness of the importance of physical activity in chronic illness management through reading comic books, training regarding warm-up stretching exercises, identifying facilitators and barriers to exercise through photosharing, supporting self-reflection and development of action plans) was developed to promote physical activity (PA) among patients with diabetes and hypertension. This study aimed to evaluate the efficacy of this intervention on health behaviour (walking) and health outcomes. Design: A non-randomized controlled trial with waitlisted control and pre- and post-measures. Setting: Community centres for the elderly. Participants: A total of 204 older adults with diabetes and/or hypertension were recruited. They were assigned to either the intervention group (IG) or waitlisted to the control group (CG). Intervention: Under the supervision of a nurse, six weekly group meetings were arranged in community centres for the elderly in which the participants freely exchanged their views regarding the barriers and facilitators of regular physical activity. Participants were encouraged to take photos in their neighbourhood or at home and brought these photos to share at the group meetings. The photos showed both the barriers and the facilitators to PA. In the last meeting, each participant worked out a plan to perform PA in the coming four weeks. Measures: PA referred to the number of steps taken per day and it was measured by a Garmin Accelerometer at baseline, Week 6 and Week 10. Other measures included the nine-item Self-Efficacy Scale for Exercise - Chinese version (SEE-C), the 23-item Chinese Barriers to Exercise Scale and Senior Fitness Tests. Generalised Estimating Equations (GEE) models compared the outcomes over time between IG and CG. Results: A statistically significant difference in the changes in the average number of steps taken daily between the two groups at Week 10 (mean difference = 965.4; 95% confidence interval: 92.2, 1838.6, p = 0.030) was observed, although the difference at Week 6 was non-significant (mean difference = 777.6; 95% confidence interval: −35.3, 1590.5, p = 0.061). IG participants also showed significant improvements in lower body strength (mean difference = 0.967; 95% confidence interval: 0.029, 1.904, p = 0.043) and lower limb flexibility (mean difference = 2.068; 95% confidence interval: 0.404, 3.731, p = 0.015) at Week 10 compared to CG participants. Conclusion: This multi-component intervention improved the participants’ physical activity level and physical fitness, particularly in lower limb flexibility and body strength.

Preprint ARTICLE | doi:10.20944/preprints202402.1623.v1

Prevalence of Type 1 and 2 Diabetes among Chronic Kidney Disease Patients and Laboratorial Differences between Them

Abdullah Shyah, Ahmad Almouselli, Taghreed Hmoud

Subject: Medicine And Pharmacology, Internal Medicine Keywords: diabetes; chronic kidney disease; diabetic nephropathy; MDRD

Online: 28 February 2024 (10:43:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0186.v1

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Nuria García-Magro, Yasmina B. Martin, Pilar Negredo, Francisco Zafra, Carlos Avendaño

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic pain; allodynia; trigeminocervical complex; glycine transporters

Online: 5 March 2021 (11:47:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.1093.v1

Microglial Responses to Stress-Induced Depression: Causes and Consequences

Ruqayya Afridi, Kyoungho Suk

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines

Online: 28 April 2023 (03:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0307.v1

Sleep Patterns of Children and Adolescents with Chronic Conditions and Their Families: An Integrative Literature Review

Welker da Silva Xavier, Madalena Paulos Abreu, Michelle Darezzo Rodrigues Nunes, Fernanda Machado Silva-Rodrigues, Liliane Faria Da Silva, Barbara Bertolossi Marta De Araújo, Paula Saud De Bortoli, Lucila Castanheira Nascimento

Subject: Public Health And Healthcare, Nursing Keywords: child; adolescent; family; chronic disease; sleep-wake disorders

Online: 4 January 2024 (15:17:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1434.v1

Exploring Chronic Patients' Views and Perceptions on Life Constraints and Self- Management Strategies. A Qualitative Study

Michael Rovithis, Sofia Koukouli, Alexios Dimitropoulos, Argyroula Kalaitzaki, Nikos Rikos, George Vasilopoulos, Aikaterini Papachristou, George Tsolas, Alexandra Tamiolaki, Eleni Tsapnidou, Anastasia Dimitrantzou, Dimitrios Katsiris, Elli Katsiri, Areti Stavropoulou

Subject: Public Health And Healthcare, Other Keywords: chronic disease; self-management; elder patients; qualitative study

Online: 21 June 2023 (08:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint ARTICLE | doi:10.20944/preprints202301.0158.v1

Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet

Ryoya Togashi, Mutsuaki Edama, Mayuu Shagawa, Haruki Osanami, Hrotake Yokota, Ryo Hirabayashi, Chie Sekine, Tomonobu Ishigaki, Hiroshi Akuzawa, Yuki Yamada, Taku Toriumi, Ikuo Kageyama

Subject: Physical Sciences, Biophysics Keywords: subtalar joint instability; chronic ankle instability; footprint osteoarthritis

Online: 9 January 2023 (09:22:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2155.v1

Effects of Beraprost with or without NOS Inhibitor on Aldosterone and Hemodynamics in Healthy Cats

Takumi Matsuura, Aritada Yoshimura, Ryuji Fukushima

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: beraprost; feline; chronic kidney disease; aldosterone; NOS

Online: 30 September 2023 (05:18:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0063.v1

A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management

Ashish Shetty, Gayathri Delanerolle, Heitor Cavalini, Yinshan Qui, Amy Boyd, Yassine Bouchareb, Anish Thillainathan, Seung Kim, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; non-pharmaceutical pain management; interventions

Online: 1 June 2023 (08:13:11 CEST)

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Background: Chronic, non-cancer pain represents a serious public health and economic issue affecting approximately 20% of the global population. Chronic pain can affect many aspects of patient’s lives, including mental health, employment, and relationships. Current medical management is largely focussed on investigating and managing acute pain. Patients and clinicians are now increasingly aware of the potential benefits of combined treatments or complex interventions in alleviating chronic pain. These approaches include both physical interventions, such as exercise or yoga, as well as psychological support including cognitive behavioural therapy (CBT) and talking therapies. Methods: This study used network meta-analyses to explore the prevalence of complex interventions in pain management, and the effects of these interventions on quality of life, using outcome measures including intensity of chronic pain, assessment of functional disability and participant’s psychological state. Results: Psychological interventions were associated with improvements in pain intensity and depression. Exercise and manipulation technique-based treatments provided a statistically significant reduction in pain intensity. This effect was enhanced when exercise and CBT were combined. Mensendieck somatocognitive therapy (MSCT) plus standard gynaecological treatment (STGT) treatments appeared to have a better effect on chronic pain than multimodal exercise plus CBT treatment. Combined MSCT and STGT treatment, and multimodal exercise plus CBT treatments, reduced pain intensity, whilst MSCT+STGT treatments had a slightly better effect than exercise plus CBT treatment.Conclusions: Complex interventions have become more popular with patients as the risks associated with other interventions including surgery and pharmacological management have become better understood. These interventions can have a significant positive effect both on the physical and psychological health of patients. The analysis presented in this study suggests that further work is warranted in this area and that additional studies are required, both in more geographically diverse locations, and with larger cohorts.

Preprint REVIEW | doi:10.20944/preprints202304.0319.v1

Recent Advances in Urinary Peptide and Proteomic Biomarkers in Chronic Kidney Disease: A Systematic Review

Lorenzo Catanese, Justyna Siwy, Harald Mischak, Ralph Wendt, Joachim Beige, Harald Rupprecht

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: biomarkers; chronic kidney disease; peptide; proteomic; urine

Online: 13 April 2023 (10:51:02 CEST)

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Background: Biomarker development, improvement, and clinical implementation in the context of kidney disease has been a central focus of biomedical research for decades. To this point, only serum creatinine and urinary albumin excretion are well accepted biomarkers in kidney disease. With their known blind spot in early stages of kidney impairment and diagnostic limitations there is a need for better and more specific biomarkers. With the rise of large-scale analysis of thousands of peptides in serum or urine samples using mass spectrometry techniques hopes for biomarker development were high. Advances in proteomic research have led to the discovery of an increasing amount of potential proteomic biomarkers and identification of candidate biomarkers for clinical implementation in the context of kidney disease management. In this review we focus on urinary peptide and especially peptidomic biomarkers emerging from recent research and underline the role of those with the highest potential for clinical implementation. Methods: The Web of Science database (all databases) was searched on October 17th, 2020, using the search terms “marker*” OR biomarker* AND “renal disease” OR “kidney disease” AND “proteome*” OR “peptid*” AND “urin*”. English, full-text original articles on humans published within the last 5 years were included which were cited at least 5 times per year. Studies based on animal models, renal transplant studies, metabolite studies, studies on miRNA and studies on exosomal vesicles were excluded focusing on urinary peptide biomarkers. Results: The described search led to the identification of 3668 articles and application of inclusion and exclusion criteria as well as abstract and consecutive full-text analysis of 3 independent authors to a final number of 62 studies for this manuscript. The 62 manuscripts encompassed 8 established single peptide biomarkers and several proteomic classifiers including CKD273 and IgAN237. Discussion: This review provides a summary of recent evidence on single peptide urinary biomarkers in CKD while emphasizing the increasing role of proteomic biomarker research with new research on established and new proteomic biomarkers. Lessons learned from the last 5 years in this review might encourage future studies hopefully resulting in routine clinical applicability of new biomarkers.

Preprint REVIEW | doi:10.20944/preprints202404.0468.v1

Neuromodulation and Habituation: A Literature Review and Conceptional Analysis of Sustaining Therapeutic Efficacy and Mitigating Habituation

Anand S. Patil, Brittni Levasseur, Mayank Gupta

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal cord stimulator; neuromodulation; explant; chronic pain; waveform; habituation

Online: 7 April 2024 (10:09:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0940.v1

18 Months Follow-Up of Deep Molecular Response 4.5 (MR4.5) with Nilotinib in Patients with Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: A Prospective, Multi-Center Study in China

Bingbing Wen, Yuming Zhang, Haiqing Lin, Jin Lou, Chuangqing Tu, Yirong Jiang, Xiaolian Liu, Yan Chen, Huiqing He, Zelin Liu, Xiaoling Xie, Wangxiang Huang, Liping Pang, Xin Du

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: 18 months; deep molecular response; nilotinib; newly diagnosed; chronic-phase chronic myeloid leukemia

Online: 13 June 2023 (12:52:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0298.v1

Insights of Endocytosis Signaling in Health and Disease

Chandramani Pathak, Foram U. Vaidya, Bhargav N. Waghela, Pradeep Kumar Jaiswara, Vishal Kumar Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu Ranjan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endocytosis; Phagocytosis; Pinocytosis; Receptor endocytosis signaling; Chronic diseases

Online: 16 December 2022 (08:07:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0545.v1

Can the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) program be provided online? Voices from the Youth

Nicholas Chadi, Elli Weisbaum, Catherine Malboeuf-Hurtubise, Sara Ahola Kohut, Christine Viner, Miriam Kaufman, Jake Locke, Dzung X. Vo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: qualitative, mindfulness, meditation, chronic illness, adolescents, eHealth

Online: 27 July 2018 (15:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0340.v1

The Efficacy and Safety of High Dose Cholecalciferol Therapy in Hemodialysis Patients

Agnieszka Tarasewicz, Michał Komorniczak, Agnieszka Zakrzewska, Bogdan Biedunkiewicz, Sylwia Małgorzewicz, Magdalena Jankowska, Katarzyna Jasiulewicz, Natalia Płonka, Małgorzata Dąbrowska, Alicja Dębska-Ślizień, Leszek Tylicki

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: vitamin D; cholecalciferol; 25-hydroxycholecalciferol, calcidiol; calcitriol; hemodialysis; parathyroid hormone; chronic kidney disease; chronic kidney disease–mineral; bone disorder

Online: 7 November 2023 (02:38:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1662.v1

A Systematic Review and Meta-Epidemiology study on Multimorbidity

Gayathri Delanerolle, Yassine Bouchareb, Priyanka Jagadeesan, Guanpeng Li, Xiaojie Yang, Heitor Cavalini, Shaheen Kazali, Alain Zemokoho, David Benfield, Ashish Shetty, Peter Phiri, Jian qing Shi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Multimorbidity; Chronic condition; Health Inequalities; Global health; Epidemiology

Online: 23 August 2023 (11:25:08 CEST)

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With enhanced life expectancy and ageing global populations, the prevalence of multimorbidity continues to increase. However, there is a dearth of evidence linked to multimorbidity diagnoses, treatments and health outcomes which remains a concern for future proofing optimal healthcare services. Generating evidence is critical to managing multimorbidity, promoting public health and minimizing health inequalities via effective healthcare policies that improve quality of life for vulnerable populations. This study assessed meta-epidemiology of multimorbidity to report the gaps in scientific knowledge and clinical practice. A systematic methodology was designed and published in PROSPERO (CRD42022347308) to report meta-epidemiology analyses using databases including PubMed, Web of Science, ScienceDirect, EMBASE, The Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials and MEDLINE for studies published between the 1^st of January 1980 - 31^st December 2022. A random-effects model was used to estimate the pooled proportion of multimorbidity in adults. Forest plots, pooled odds ratios and statistical heterogeneity metrics were used to assess the association between multimorbidity and investigated factors. Funnel plots and Egger’s regression were used to detect and correct for publication bias. Our findings identified women to be 0.32 times more likely to have multimorbidity in comparison to males. In regard to ethnicity, white people were 0.47 times less likely to develop comorbidities than black people. People who identified as a drinker or unmarried were more likely to develop comorbidities than those who are non-drinkers or married, respectively. Regardless of smoking status, people were equally likely to have comorbidity. In terms of environmental influences, people in rural areas were found to be 0.2 times less likely to have comorbidity in comparison to those living in urban areas. Interestingly, people with a higher education level were 0.57 times more likely to develop comorbidities than those with only a high school education. It is evident that multimorbidity has a significant burden globally and impacts the provision of care necessitated across populations given its association with several social determinants of health. Robust research and healthcare policies are required to better manage multimorbidity in patients. An example of such intervention includes employing prevention programs to reduce risk and incidence of multimorbidity within at-risk populations.

Preprint REVIEW | doi:10.20944/preprints202305.0643.v1

Cells and Processes in Wound Healing: More Recent Advances

Montserrat Fernández-Guarino, María Luisa Hernández-Bule, Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: Acute Wounds; Cellular Infiltrate; Chronic Wounds; Keloids; Scars

Online: 9 May 2023 (11:06:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0146.v2

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina, Enric Espel

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment

Online: 29 September 2017 (03:17:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1632.v1

The Efficacy of a Novel Compound from Bovine Milk Colostrum Exosomes and Its Growth Factors in Enhancing the Process of Wound Healing

Mojgan Najafzadeh, Shohreh Jafarinejad, Adi Baumgartner, Jacobo Elies Gomez

Subject: Medicine And Pharmacology, Dermatology Keywords: Bovine Colostrum; Wound healing; Repair; Chronic wound

Online: 23 January 2024 (07:27:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0238.v1

Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease

Sonia Mota-Zamorano, Guadalupe García-Pino, Guillermo Gervasini

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; renal transplant; arachidonic acid; adipose tissue

Online: 3 January 2024 (09:58:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1162.v1

CfDNA and Caspase-3 Levels in Patients with Chronic Kidney Disease

Anna Clementi, Grazia Maria Virzì, Sabrina Milan Manani, Massimo De Cal, Giovanni Giorgio Battaglia, Claudio Ronco, Monica Zanella

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: cell free DNA, caspase-3, chronic kidney disease,

Online: 16 June 2023 (03:31:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0303.v1

Analysis of the Dimensions of Physiotherapy Index of Ventilatory Workload in People with Chronic Obstructive Pulmonary Disease During Stability and Exacerbation in An Outpatient Setting

Rodrigo Muñoz Cofré, Mariano del Sol, Paul Medina González, Jorge Valenzuela Vásquez, Gerardo Molina Vergara, Ramón Pinochet Urzúa, Pablo A. Lizana, Máximo Escobar Cabello

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ventilatory assessment; physiotherapy; chronic obstructive pulmonary disease

Online: 29 August 2019 (04:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0050.v1

The FDA and the State of Chronic Diseases: Cardiovascular, Endocrine, Pulmonary, and Renal Diseases

Mona Fiuzat, Michael P. Gray, Grace Anne Dorney Koppel, Aaron Kowalski, Prabir Roy-Chaudhury, Mary Norine Walsh, Daniel W. Jones, Enid Neptune, Robert Ratner, Melissa West, Brad A. Wong, Robert Califf

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic diseases; cardiovascular; renal; endocrine; diabetes; therapeutic advances; tobacco

Online: 3 May 2018 (05:08:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0100.v1

Electrocardiogram, Echocardiogram and NT-proBNP in Screening for Thromboembolism Pulmonary Hypertension in Patients after Pulmonary Embolism

Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Iwona Dudzik-Niewiadomska, Michał Machowski, Marek Roik, Małgorzata Wiśniewska, Jan Siwiec, Izabela Magdalena Staniszewska, Piotr Pruszczyk

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: screening after pulmonary embolism; chronic thromboembolic pulmonary disease; chronic thromboembolic pulmonary hypertension; diagnostic work-up of post-pulmonary syndrome

Online: 9 October 2022 (02:09:20 CEST)

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Background: The annual mortality of patients with untreated chronic thromboembolism pulmonary hypertension (CTEPH) is approximately 50% unless a timely diagnosis is followed by adequate treatment. In pulmonary embolism (PE) survivors with functional limitation the diagnostic work-up starts with echocardiography. It is followed by lung scintigraphy and right heart catheterization. However, noninvasive test providing diagnostic clues to CTEPH, or ascertain this diagnosis as very unlikely, would be extremely useful since the majority of post PE functional limitations is caused by deconditioning. Methods: Patients after acute PE underwent a structured clinical evaluation with electrocardiogram, routine laboratory tests including NT-proBNP and echocardiography. The aim of study was to verify whether the parameters from echocardiographic or perhaps electrocardiographic examination and NT-proBNP concentration best determine the risk of CTEPH. Results: A total (n = 261, male n = 123) patients after PE were included into the study, in group of 155 patients (59.4%) with reported functional impairment 13 patients (8.4%) had CTEPH and 7 PE survivors had chronic thromboembolic pulmonary disease (CTEPD) (4,5%). Echo parameters differed significantly between CTEPH/CTEPD cases and other symptomatic PE survivors. Patients with CTEPH/CTEPD had also higher level of NT-proBNP (p = 0.022) but concentration of NT-proBNP above 125 pg/ml did not differentiate patients with CTEPH/CTEPD (p>0.05). Additionally, proportion of patients with right bundle brunch block registered in ECG was higher in group with CTEPH/CTED (23.5% vs. 5.8%, p = 0.034) but there were no differences between other ECG characteristics of right ventricle overload. Conclusion: Screening for CTEPH/CTEPD should be performed in patients with reduced exercise tolerance compared to pre PE period, It is not effective in asymptomatic PE survivors. Patients with CTEPH/CTED had predominantly abnormalities indicatingchronic thromboembolism in the echocardiographic assessment. NT-proBNP and electrocardiographic characteristics of right ventricle overload proved to be insufficient in predicting CTEPH/CTEPD development.

Preprint ARTICLE | doi:10.20944/preprints202403.1307.v1

The Role of Pistacia lentiscus in the Prevention of Chronic Rhinosinusitis Recurrence

Alberto Macchi, Camilla Czaczkes, Maurizio Bignami, Giulia Monti

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Chronic Rhinosinisitis; Pistacia Lentiscus; Biofilm

Online: 26 March 2024 (03:00:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1436.v1

Cognitive Impairment and Brain Atrophy in Patients with Non-Dialysis and Dialysis Dependent Chronic Kidney Disease

Kazuhiko Tsuruya, Hisako Yoshida

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: brain atrophy; cognitive impairment; chronic kidney disease; dialysis; exercise

Online: 18 January 2024 (15:58:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0346.v1

A Highly Transparent and Explainable Artificial Intelligence Tool for Chronic Wound Classification: XAI-CWC

Salih Sarp, Murat Kuzlu, Emmanuel Wilson, Umit Cali, Ozgur Guler

Subject: Engineering, Control And Systems Engineering Keywords: Chronic wound classification; transfer learning; explainable artificial intelligence.

Online: 18 January 2021 (14:28:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1753.v1

A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management

Ashish Shetty, Gayathri Delanerolle, Chunli Deng, Heitor Cavalini, Xiaojie Yang, Anish Thillainathan, Yassine Bouchareb, Amy Boyd, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Chronic pain; Medical Devices; Neuromodulation; Clinical trials; Bayesian

Online: 25 May 2023 (07:27:31 CEST)

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Chronic non-cancer pain is a highly debilitating condition affecting approximately 20% of the global population. Chronic pain may lead to significant physical disability, emotional distress, social isolation and financial burden. Whilst^.pharmacological therapies remain the cornerstone of pain management in non-cancerous chronic pain, factors including the current opioid epidemic have led to non-pharmacological techniques becoming a more attractive proposition. We explored the prevalence of medical device use and their treatment efficacy in non-cancer pain management. A systematic methodology was developed, peer reviewed and published in PROSPERO (CRD42021235384). Key words of medical device, pain management devices, chronic pain, lower back pain, back pain, leg pain and chronic pelvic pain using Science direct, PubMed, Web of Science, PROSPERO, MEDLINE, EMBASE, PorQuest and ClinicalTrials.gov. All clinical trials, epidemiology and mixed methods studies that reported the use of medical devices for non-cancer chronic pain management published between the 1^st of January 1990 and the 30^th of April 2022 were included. 13 studies were included in systematic review, of these 6 were used in the meta-analysis with 173 participants. Our meta-analysis for pain reduction in each study showed that transcutaneous electrical nerve stimulation combined with instrument-assisted soft tissue mobilization treatment and pulsed electromagnetic therapy produced significant treatment on chronic lower back pain patients. Pooled evidence revealed the use of medical device related interventions resulted in 0.7 degree of pain reduction under a 0-10 scale. Significant improvement in disability scores, with a 7.44 degree reduction in disability level compared to a placebo using a 50 score range was also seen. The application of medical devices in patients with chronic pain has gained popularity due to increasingly cost effective techniques, minimally invasiveness and greater awareness of risks associated with pharmacological management. Our analysis has shown that the optimal use of medical devices in a sustainable manner requires further extensive research, needing larger cohort studies with greater gender parity, in a more diverse range of geographical locations.

Preprint ARTICLE | doi:10.20944/preprints202212.0224.v1

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Varvara A Ryabkova, Natalia Y Gavrilova, Alina A Poletaeva, Aleksandr I Pukhalenko, Irina A Koshkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome; autoantibodies; autoimmunity

Online: 13 December 2022 (02:47:48 CET)

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(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.

Preprint ARTICLE | doi:10.20944/preprints202106.0493.v1

Long-term recovery of the fecal microbiome and metabolome of dogs with steroid-responsive enteropathy

Rachel Pilla, Blake Guard, Amanda B Blake, Mark Ackermann, Craig Webb, Steve Hill, Jonathan A Lidbury, Joerg M Steiner, Albert Jergens, Jan Suchodolski

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Chronic diarrhea, idiopathic inflammatory bowel disease, microbiota, dysbiosis

Online: 21 June 2021 (08:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2096.v1

The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats- a Long-Term Study

Brian G Murphy, Diego Castillo, Sarah Elisabeth Cook, Chrissy Eckstrand, Samantha Evans, Ellen Sparger, Chris Grant

Subject: Biology And Life Sciences, Virology Keywords: Cat; FIV; lentivirus; FAIDS; lymphoma; chronic renal failure

Online: 31 July 2023 (10:29:19 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202305.0453.v1

Development of a Modified Global Physical Activity Questionnaire and its Construct Validity among Adults in Kerala, India

Thirunavukkarasu Sathish, Elezebeth Mathews

Subject: Public Health And Healthcare, Other Keywords: physical activity; GPAQ; validity; self-reports; chronic diseases

Online: 8 May 2023 (05:20:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0749.v1

Unveiling the Landscape of COVID-19 Vaccination in Saudi Arabia: A Socio-Demographic, Clinical, and Vaccine Profile Analysis

Gehad Subaiea, Nawaf Alkhateeb, Faisal Sahman, Abdulrahman Alsudayri, Abdulkarim Mohammed Almudayni, Hamoud Alrashidi, Abdulrahman Majid Alshammari, Ahmed Alsolami, Abdulmalik M. Alqarni, Abdulwahab Alamri, Yasser Alhabeeb, Sirajudheen Anwar

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19 vaccination; Saudi Arabia; Cross-sectional study; Socio-demographic characteristics; Chronic conditions; Vaccine administration; Infection rates

Online: 13 February 2024 (12:40:53 CET)

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The worldwide competition to vaccinate against COVID-19 has highlighted the importance of immunization measures in containing the virus. Saudi Arabia, like the rest of the globe, must assess socio-demographic subtleties, chronic illnesses, vaccination effects, and public health policy implications as it navigates this complicated environment. This cross-sectional study examined Saudi COVID-19 vaccine in many ways. It examined the socio-demographic makeup of vaccine recipients, the prevalence of chronic conditions in this population, vaccine administration patterns, post-vaccination side effects, and vaccine-infection rates. A questionnaire-based online survey of 401 participants ensured gender, nationality, age, weight, and educational diversity. We analyzed vaccine manufacturer choice for each dosage, side effects after the first and second doses, and chronic diseases in the sample. Pfizer/BioNTech vaccines are preferred for all three doses, reflecting worldwide vaccination acceptance patterns. Side effects were not significantly different between vaccination kinds. Interestingly, immunization reduced infection rates, demonstrating the efficacy of COVID-19 vaccines. The data fills important information gaps and illuminates Saudi COVID-19 vaccination kinetics. These data support the global preference for mRNA vaccines, demonstrating the faith in this breakthrough technology. They also sponsor COVID-19 vaccine safety and effectiveness studies. The dramatic drop in infection rates among vaccinated people shows how vaccinations suppress the pandemic. These findings inform Saudi Arabia's immunization efforts. As booster doses become more common, long-term vaccination research is crucial. Vaccine reluctance, especially in certain demographics, must be addressed. Due to vaccines' protective potential, equitable vaccine distribution and large immunization programs are essential for herd immunity and pandemic management. This thorough cross-sectional study helps policymakers and healthcare practitioners build successful and inclusive COVID-19 immunization regimens in Saudi Arabia.

Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0145.v1

Associations between Physical Disability and Chronic Diseases with Depressive Symptoms in Vietnamese-Origin Older Adults in the United States

Christina E Miyawaki, Joshua M Garcia, Luis D Medina, Kim N Nguyen, Oanh L Meyer, Kyriakos S Markides

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic diseases; depressive symptoms; disability; older adults; Vietnamese

Online: 3 January 2024 (08:39:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1522.v1

A Review and Meta-Analysis of the Effect of Atenolol on All-Cause Mortality Risk among Asians With Chronic Progressive Diseases

Abdullah Alkattan, Eman Alsalameen, Alaa Harmoush, Mhd Nour Farawati, Hind Alsharif, Nagla Mahmoud, Mhd Ali Farawati, Amjad Alfaleh, Mahmoud Kandeel, Nashwa Radwan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Atenolol; mortality; Asians; chronic progressive disease; cardiovascular disease

Online: 22 September 2023 (04:36:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0567.v1

Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis

Leonid L Bershtein, Alexey Sumin, Elizaveta Zbyshevskaya, Victoria Gumerova, Darejan Tsurtsumia, Igor Kochanov, Alina Andreeva, Vartan Piltakian, Sergey Sayganov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic coronary syndromes; revascularization; prognosis; ISCHEMIA; ISCHEMIA-EXTEND

Online: 8 June 2023 (02:13:16 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0320.v1

Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies

Pedro Henrique Franca Gois, Martin Wolley, Dwarakanathan Ranganathan, Antonio Carlos Seguro

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: vitamin D; vitamin D deficiency; chronic kidney disease; proteinuria

Online: 18 July 2018 (08:39:27 CEST)

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