Version 1
: Received: 29 December 2023 / Approved: 3 January 2024 / Online: 3 January 2024 (09:58:58 CET)
How to cite:
Mota-Zamorano, S.; García-Pino, G.; Gervasini, G. Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease. Preprints2024, 2024010238. https://doi.org/10.20944/preprints202401.0238.v1
Mota-Zamorano, S.; García-Pino, G.; Gervasini, G. Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease. Preprints 2024, 2024010238. https://doi.org/10.20944/preprints202401.0238.v1
Mota-Zamorano, S.; García-Pino, G.; Gervasini, G. Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease. Preprints2024, 2024010238. https://doi.org/10.20944/preprints202401.0238.v1
APA Style
Mota-Zamorano, S., García-Pino, G., & Gervasini, G. (2024). Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease. Preprints. https://doi.org/10.20944/preprints202401.0238.v1
Chicago/Turabian Style
Mota-Zamorano, S., Guadalupe García-Pino and Guillermo Gervasini. 2024 "Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease" Preprints. https://doi.org/10.20944/preprints202401.0238.v1
Abstract
This review provides insight into the role that obesity, but especially mediators of the adipose tissue, have in both renal disease and transplantation. In particular, we focus on the functions of leptin and adiponectin, inflammatory mediators with widely known clinical implications, as well as on the role of arachidonic acid-derived eicosanoid metabolites. These latter compounds, epoxyeicosatrienoic (EETs) and hydroxyeicosatetraenoic (HETEs) acids, which modulate the liberation of cytokines in the adipose tissue, are generated in the epoxygenase pathway of arachidonic biotransformation via CYP450 enzymes. There is accumulating evidence suggesting that EETs and HETEs may have a critical role in the onset and outcome of chronic kidney disease and renal transplantation. Finally, we also discuss the reported effect that the presence of genetic variants in leptin, adiponectin, EETs and HETEs-related genes may cause in renal patients and recipients. The levels of cytokines of the adipose tissue and related compounds play a remarkable role in both renal disease and transplant. Accordingly, novel therapeutic strategies are being developed based on the modulation of their concentrations in patients with various diseases.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
