Search | Preprints

Anna Crispo, Maria Teresa Corradin, Erika Giulioni, Antonella Vecchiato, Paolo Del Fiore, Paola Queirolo, Francesco Spagnolo, Vito Vanella, Corrado Caracò, Giulio Tosti, Elisabetta Pennacchioli, Giuseppe Giudice, Eleonora Nacchiero, Pietro Quaglino, Simone Ribero, Monica Giordano, Desire Marussi, Stefania Barruscotti, Michele Guida, Vincenzo De Giorgi, Marcella Occelli, Federica Grosso, Giuseppe Cairo, Alessandro Gatti, Daniela Massa, Laura Atzori, Nicola Calvani, Tommaso Fabrizio, Giuseppe Mastrangelo, Federica Toffolutti, Egidio Celentano, Mario Budroni, Sara Gandini, Carlo Riccardo Rossi, Alessandro A. E. Testori, Giuseppe Palmieri, Paolo A. Ascierto

Subject: Medicine & Pharmacology, Allergology Keywords: medical record systems; cutaneous malignant melanoma; survival analysis; immunotherapy

Online: 29 October 2020 (16:02:44 CET)

Show abstract| Download PDF| Share

Background: Cutaneous malignant melanoma (CMM) is one of the most aggressive types of skin cancer. Currently, innovative approaches such as target therapies and immunotherapies have been introduced in clinical practice for the treatment of metastatic CMM. Data of clinical trials and real life studies that evaluate the outcomes of these therapeutic associations are necessary to establish their clinical utility. The aim of this study is to investigate the types of oncological treatments employed in the real-life clinical management of patients with advanced CMM in several Italian centers which are part of the Clinical National Melanoma Registry (CNMR), and the oncological outcomes obtained. Methods: CNMR collects data of patients with a histologically confirmed diagnosis of primary CMM treated in one of the 38 Italian institutions (hospitals, research institutes, etc.) participating in the network. Melanoma-specific survival and Overall survival were calculated. Kaplan-Meier curves and medians of OS and 95% CI are presented overall and by immunotherapy and target treatments. The Log-rank test compared curves by treatments. Multivariate Cox regression models were used to estimate the hazard ratios adjusting for confounders and other prognostic factors. Results: The median follow-up time was 36 months (range 1.2-185.1). 787 CMM were included in the analysis with completed information about therapies.Global immunotherapy showed a significant improved survival compared with all other therapies (p=0.001). 75% was the highest reduction of death reached by nivolumab/pembrolizumab immunotherapy (anti-PD1 HR=0.25 95% CI 0.14-0.42), globally immunotherapy was significantly associated with improved survival, either for anti-CTL A4 monotherapy or combined with anti-PD1 (HR=0.47;95% CI 0.33-0.66 and HR=0.26; 95% CI 0.15-0.46, respectively). Conclusions: The nivolumab/pembrolizumab and the combination of ipilimumab can be considered the best therapy to improve survival in a real-world-population. The CNMR can complement clinical registries with the intent of improving cancer management and standardizing cancer treatment.

Preprint ARTICLE | doi:10.20944/preprints202009.0380.v1

The Correlations between CXCL12, CXCR4, EAAT1 and GS in Malignant Pleural Mesothelioma, and CXCL12 Regulates Cell Invasion and Migration via CXCR4/EAAT1/GS Pathway

Shuo Li, Tong Li, Qiang Lin, Debing Shi, Haishi Zheng, Jin Zhang, Hui Li, Shengcai Hou, Orli Kadoch, Yilin Yang, Zhidong Xu

Subject: Medicine & Pharmacology, General Medical Research Keywords: malignant pleural mesothelioma; CXCL12/CXCR4; EAAT1; glutamine synthetase; invasion; migraiton

Online: 17 September 2020 (07:29:16 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0117.v1

Identification of Malignant Mesothelioma Risk Factors through Association Rule Mining

Talha Mahboob Alam

Subject: Medicine & Pharmacology, General Medical Research Keywords: malignant mesothelioma; epidemiology; association rule mining; Apriori method; imbalanced dataset

Online: 10 November 2019 (16:15:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0325.v1

Foxp3 and CD68 as Potential Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Solid Tumor

Peter Grell, Simona Borilova, Pavel Fabian, Iveta Selingerova, David Novak, Petr Muller, Igor Kiss, Rostislav Vyzula

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Immune checkpoint inhibitors; Anti-tumor immunity; Predictive biomarker; Malignant melanoma; NSCLC

Online: 18 January 2023 (08:39:18 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202208.0452.v1

Evolutionary View on Lactate-Dependent Mechanisms of Maintaining Cancer Cells Stemness and Reprimitivization

Petr V. Shegay, Anastasia A. Zabolotneva, Olga P. Shatova, Aleksandr V. Shestopalov, Andrei D. Kaprin

Subject: Biology, Other Keywords: lactate; lactic acid; glycolysis; carcinogenesis; malignant tumor; evolutionary oncology; Warburg effect

Online: 26 August 2022 (07:13:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0229.v1

Rapid Intraoperative Detection of Residual Glioma Cell in Resection Cavity Walls Using a Compact Fluorescence Microscope

Jiro Akimoto, shinjiro Fukami, Megumi Ichikawa, Kenta nagai, Michihiro Kohno

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: intraoperative photodiagnosis; malignant glioma; fluorescence-guided surgery; intraoperative cytology; fluorescence microscope

Online: 14 September 2021 (10:02:54 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0686.v1

The Role of Biomaterials in Upper Digestive Tract Transoral Reconstruction

Raluca Grigore, Bogdan Popescu, Serban Vifor Gabriel Bertesteanu, Cornelia Nichita, Irina Doinita Oasa, Gloria Simona Munteanu, Alexandru Nicolaescu, Paula Luiza Bejenaru, Catrinel Beatrice Simion Antonie, Dragos Ene, Razvan Ene

Subject: Medicine & Pharmacology, Allergology Keywords: malignant neoplasia; transoral reconstruction; polydimethyl siloxane; Ag nanoparticles; fatigue strenght; prosthesis

Online: 28 December 2020 (11:24:53 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202002.0209.v1

Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application

Sonali Nayak, Ashorne Mahenthiran, Yongyong Yang, Mark McClendon, Barnara Mania-Farnell, Charles David James, John A. Kessler, Tadanori Tomita, Shi-yuan Cheng, Samuel Stupp, Guifa Xi

Subject: Life Sciences, Molecular Biology Keywords: bone morphogenetic protein 4; molecular mechanism; delivery; clinical application; malignant glioma

Online: 16 February 2020 (04:19:22 CET)

Show abstract| Share

Preprint ARTICLE | doi:10.20944/preprints201910.0373.v1

The Hidden Story on Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma – Association with Clinical Outcome and Tumor Phenotypes

Lazaro Hiram Betancourt, A. Marcell Szasz, Magdalena Kuras, Jimmy Rodriguez Murillo, Yutaka Sugihara, Indira Pla, Zsolt Horvath, Krzysztof Pawlowski, Melinda Rezeli, Kenichi Miharada, Jeovanis Gil, Jonatan Eriksson, Roger Appelqvist, Tasso Militois, Bo Baldetorp, Christian Ingvar, Håkan Olsson, Lotta Lundgren, Peter Horvatovich, Charlotte Welinder, Elisabet Wieslander, Ho Jeong Kwon, Johan Malm, Istvan Balazs Nemeth, Göran Jönsson, David Fenyo, Aniel Sanchez, György Marko-Varga

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: malignant melanoma; BRAF V600E mutation; proteomics; mass spectrometry genetics; heterogeneity; prognosis

Online: 31 October 2019 (10:36:32 CET)

Show abstract| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202201.0208.v1

Advance Directives in Oncology and Haematology: A Long Way to Go. A Narrative Review

Kevin Serey, Amélie Cambriel, Adrien Pollina-Bachellerie, Jean-Pierre Lotz, François Philippart

Subject: Life Sciences, Other Keywords: End of Life; Advance Directives; Advance Care Planning; Intensive Care, Medical Oncology; malignant hemopathy

Online: 14 January 2022 (11:34:51 CET)

Show abstract| Share

Preprint ARTICLE | doi:10.20944/preprints201910.0229.v1

Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma

Vithushiya Yoganandarajah, Josie Patel, Bede van Schaijik, Nicholas Bockett, Helen D. Brasch, Erin Paterson, Dalice Sim, Paul F. Davis, Imogen Roth, Tinte Itinteang, Swee T. Tan

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: malignant melanoma; head and neck cancer; cancer stem cell; melanoma metastasis; induced pluripotent stem cell

Online: 19 October 2019 (17:15:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0557.v1

Coquaternions, Metric Invariants of Biologic Systems and Malignant Transformations

Garri Davydyan

Subject: Biology, Other Keywords: biologic system; feedback; malignant transformations; Lie algebra; coquaternion; indefinite metric; quadratic form; hierarchy; entropy; anabolism; catabolism

Online: 29 December 2022 (09:10:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0148.v2

Coquaternions, Metric Invariants of Biologic Systems and Malignant Transformations

Garri Davydyan

Subject: Biology, Other Keywords: biologic system; feedback; malignant transformations; Lie algebra; coquaternion; indefinite metric; quadratic form; hierarchy; entropy; anabolism, catabolism

Online: 21 October 2022 (03:58:52 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201712.0052.v1

Programming of Cell Resistance to Genotoxic and Oxidative Stress

Ilya O. Velegzhaninov, Vitaliy A. Ievlev, Yana I. Pylina, Dmitry M. Shadrin, Olesya M. Vakhrusheva

Subject: Biology, Other Keywords: cell programming; stress resistance; gene overexpression; radiation; oxidative stress; chemical genotoxins; malignant transformation; diversity of mechanisms

Online: 9 December 2017 (13:26:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0280.v1

Early Diagnosis of Oral Cancer and Lesions in Fanconi Anemia Patients: A Prospective and Longitudinal Study Using Saliva and Plasma

Ricardo Errazquin, Estela Carrasco, Sonia Del Marro, Anna Suñol, Jorge Peral, Jessica Ortiz, Juan C. Rubio, Carmen Segrelles, Marta Dueñas, Alicia Garrido-Aranda, Martina Álvarez, Cristina Belendez, Judith Balmaña, Ramon Garcia-Escudero

Subject: Life Sciences, Genetics Keywords: Fanconi anemia; oral cancer; oral potentially malignant lesion; liquid biopsy; saliva; oral rinse; plasma; next generation sequencing; cancer gene panel; early diagnosis; diagnostic test; deep sequencing

Online: 16 January 2023 (09:10:06 CET)

Show abstract| Download PDF| Share

Working Paper REVIEW

Updates on the Role of Molecular Alterations and NOTCH Signaling in the Development of Neuroendocrine Neoplasms

Claudia von Arx, Monica Capozzi, Elena López-Jiménez, Alessandro Ottaiano, Fabiana Tatangelo, Annabella Di Mauro, Guglielmo Nasti, Maria Lina Tornesello, Salvatore Tafuto

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Neuroendocrine Neoplasms; NOTCH; cancer driven genes; mutational mechanism; germline mutations.; small cell lung carcinoma; pancreatic NET; small bowel NET; medullary thyroid carcinoma; malignant castration-resistant prostatic cells

Online: 23 July 2019 (10:34:50 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.3390/sci2030068

Perspectives on Topical Medical Research in the COVID-19 Era

Michael McAleer

Subject: Keywords: COVID-19; pooling clinical trials; hyperinfection; steroids; treatment; targeted healthcare; population health management; cancer treatment; clinical research; clinical trials; developing vaccines; ranking and rating hospital quality; school closures; interventions for delirium; assessments of COVID-19 death inequities; regulatory safeguards; preventing child abuse and maltreatment; prevalence of health care worker burnout; nursing home ratings; challenging oncology practice; addressing racial; ethnic; social and economic divides; violence against sexual minority adolescents; primary tumors; metastasis; stages of cancer; reforming cancer clinical trials; supporting carers; protection and prevention; benign and malignant tumors; reforming cancer clinical trials; protection of healthcare personnel; comparing excess deaths in NYC; 1918 influenza pandemic; the possibility of full recovery from COVID-19; mental health impact of COVID-19 on young adults; ranking and rating nursing home quali

Online: 21 August 2020 (00:00:00 CEST)

Show abstract| Share

Search Results

20 articles found