Patient-Specific Hemodynamic and Angiographic Evaluation of a Novel Flow-Diverting Device for Intracranial Aneurysms

Objective: Flow-diverting devices treat intracranial aneurysms by modifying blood exchange between the parent artery and aneurysm. We quantified local flow changes after implantation using patient-specific Computational Fluid Dynamics(CFD). Methods: Three patients were evaluated: two treated with a flow-diverting device alone and one with adjunctive coiling. Patient-specific vascular models were reconstructed from clinical images. Devices and coils were virtually deployed, and steady-state CFD with explicit device geometry compared untreated and treated conditions. Findings were descriptively compared with immediate and 12-month angiography. Results: Device implantation redistributed lesion-region flow and reduced mean velocity by 11.9%, 29.4%, and 6.7% in Cases 1-3. In the giant aneurysm, adjunctive coiling produced additional reductions of 65.1% in sac-averaged velocity and 17.7% in neck-plane velocity. Immediate angiography showed contrast stasis in all cases. At 12 months, all lesions were completely occluded and parent arteries remained patent, consistent with the direction of flow suppression observed by CFD. Conclusion: Across these representative patient-specific configurations, the device produced local flow redirection while preserving parent-artery patency. Adjunctive coiling provided additional intra-saccular flow suppression in the giant aneurysm case.