The authors examined the psychophysiological effects before and after the treatment with the aim of clarifying the effects on the mind and body of continuous treatment on the head (hereinafter referred to as head-therapy). As a result, psychologically, negative emotions such as fatigue, stress awareness, depression, and anxiety decreased significantly immediately after the treatment, and positive emotions such as a feeling of clarity of mind, concentration, and exhilaration were significantly increased. Thirty minutes after the treatment, these positive emotions were even higher. Physiologically, immediately after the head-therapy, the parasympathetic nervous system activity was significantly higher than before the treatment. On the other hand, no noticeable changes were observed in central nervous system activity. Furthermore, 30 minutes after the head-therapy, the parasympathetic nervous system activity dominant state seen immediately after the treatment was maintained. It was suggested that the central nervous system activity, which did not show significant changes immediately after the treatment, was more active than before the head-therapy.