Submitted:
03 June 2026
Posted:
04 June 2026
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Abstract
Objective: To examine changes in functional status, mental health, and quality of life among older adults participating in the CEDIAM program in the Maule Region of Chile in 2022 and 2023. Methods: Pre-post observational study using routinely collected data from 15 CEDIAM centers. The 2022 and 2023 datasets were analyzed as independent cohorts. Functional status was assessed with the Barthel Index (BI), Lawton and Brody scale (L&B), and Timed Up and Go test (TUG); mental health with the Mini-Mental State Examination (MMSE) and Geriatric Depression Scale-15 (GDS-15); and quality of life with the EuroQol-5D visual analogue scale (EQ-5D). Paired comparisons, category-transition analyses, and multivariable logistic regression models of improvement were performed. Results: Baseline samples included 894 participants in 2022 and 897 in 2023. In 2022, all continuous outcomes improved significantly (all p≤0.001). In 2023, BI, TUG, GDS-15, and EQ-5D improved (all p<0.01), whereas L&B (p=0.204) and MMSE (p=0.725) did not. Category-transition analyses showed significant improvements in BI and TUG in both cohorts (both p<0.001), while significant categorical changes in L&B, MMSE, GDS-15, and EQ-5D were observed only in 2022 (all p≤0.01). Rural residence was associated with higher odds of BI improvement (OR 1.62, 95% CI 1.17-2.25; p=0.004), whereas age ≥75 years was associated with lower odds of improvement in GDS-15 (OR 0.56, 95% CI 0.41-0.76; p<0.001) and EQ-5D (OR 0.65, 95% CI 0.45-0.94; p=0.023). Conclusion: Participation in CEDIAM was associated with favorable changes, particularly in basic functional status and mobility, although responses varied across outcomes and participant subgroups.

Keywords:
1. Introduction
2. METHODOLOGY
2.1. Study design and data source
2.2. Participants
2.3. Geriatric assessment and study outcomes
2.4. Functional status
2.5. Mental health
2.6. Quality of life
2.7. Definition of improvement
2.8. Covariates
2.9. Statistical analysis
2.10. Data authorization and ethical considerations
3. RESULTS
3.1. Baseline characteristics of the 2022 and 2023 cohorts
3.2. Changes in continuous scores between entry and exit
3.3. Category transitions between entry and exit



3.4. Factors associated with improvement across outcomes
4. DISCUSSION
5. CONCLUSION
Supplementary Materials
Competing interest statement
Funding statement
References
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| Variables | 2022 (n=894) | 2023 (n=897) | p-value |
|---|---|---|---|
| Age (years) (median (IQR)a | 74 (68-78) | 73 (68-77.5) | 0.081 |
| Sex n (%)b | 0.830 | ||
| Women | 718 (80.3) | 724 (80.5) | |
| Men | 176 (19.7) | 173 (19.5) | |
| Residence n (%)b | <0.0001 | ||
| - Urban | 724 (81) | 647 (72.1) | |
| - Rural | 170 (19) | 250 (27.8) | |
| Multimorbidity n (%)b | <0.0001 | ||
| - < 2 diseases | 495 (55.4) | 411 (45.9) | |
| - ≥ 2 diseases | 399 (44.6) | 486 (54.1) | |
| Education level n (%)b | 0.346 | ||
| - Low education (≤ primary completed) | 542 (60.5) | 532 (59.2) | |
| - Higher education (≥ secondary uncompleted) | 327 (36.6) | 352 (39.1) | |
| - Unregistered | 25 (2.9) | 13 (1.4) | - |
| 2022 | ||||
|---|---|---|---|---|
| Functional status | ||||
| Scales | n (paired) | Entry (median [IQR]) | Exit (median [IQR]) | p-value |
| BI | 556 | 90 (85–95) | 90 (85–85) | <0.0001 |
| L&B | 437 | 7 (6–8) | 8 (7–8) | <0.0001 |
| TUG | 348 | 10 (8–13) | 9 (8–12) | <0.0001 |
| Mental health | ||||
| MMSE | 348 | 26 (20.3–29) | 27 (21.3–30) | <0.0001 |
| GDS-15 | 372 | 6 (3–10) | 5 (3–8) | <0.0001 |
| Quality of life | ||||
| EQ-5D | 324 | 60 (12–80) | 70 (14.8–80) | <0.001 |
| 2023 | ||||
|---|---|---|---|---|
| Functional status | ||||
| Scales | n (paired) | Entry (median [IQR]) | Exit (median [IQR]) | p-value |
| BI | 363 | 90 (85–95) | 95 (90–95) | <0.0001 |
| L&B | 353 | 7 (7–8) | 8 (7–8) | 0.204 |
| TUG | 276 | 9 (7–11) | 8 (7–10) | <0.0001 |
| Mental health | ||||
| MMSE | 336 | 27 (22–30) | 27 (23–30) | 0.725 |
| GDS-15 | 284 | 5 (2–9) | 4 (2–7) | <0.0001 |
| Quality of life | ||||
| EQ-5D | 223 | 60 (11–80) | 60 (11–80) | <0.01 |
| Barthel Index | Lawton & Brody | Timed Up and Go | ||||
|---|---|---|---|---|---|---|
| Covariate | OR (CI 95%) | p-value | OR (CI 95%) | p-value | OR (CI 95%) | p-value |
| Residence (rural) | 1.62 (1.17–2.25) | 0.004 | 1.38 (0.94–2.04) | 0.105 | 1.05 (0.73–1.51) | 0.788 |
| Sex (woman) | 0.86 (0.61–1.20) | 0.366 | 0.62 (0.42–0.93) | 0.019 | 1.15 (0.78–1.68) | 0.487 |
| Age ≥75 years | 0.98 (0.74–1.29) | 0.866 | 1.17 (0.83–1.66) | 0.360 | 1.02 (0.74–1.4) | 0.915 |
| Low educational level | 0.87 (0.66–1.15) | 0.326 | 1.36 (0.95–1.94) | 0.097 | 1.29 (0.93–1.78) | 0.133 |
| Multimorbidity (≥2 diseases) | 0.97 (0.70–1.35) | 0.851 | 0.55 (0.36–0.84) | 0.005 | 1.30 (0.82–2.06) | 0.259 |
| Hypertension | 0.79 (0.51–1.21) | 0.271 | 0.57 (0.34–0.98) | 0.041 | 0.89 (0.51–1.54) | 0.672 |
| Type 2 diabetes mellitus | 0.50 (0.18–1.11) | 0.083 | 0.16 (0.04–0.98) | 0.017 | 0.48 (0.17–1.34) | 0.160 |
| Mini-Mental State Examination | Geriatric Depression Scale | |||
|---|---|---|---|---|
| Covariate | OR (CI 95%) | p-value | OR (CI 95%) | p-value |
| Residence (rural) | 0.92 (0.6–1.37) | 0.677 | 1.02 (0.71–1.47) | 0.904 |
| Sex (woman) | 1.21 (0.81–1.80) | 0.347 | 1.08 (0.74–1.57) | 0.697 |
| Age ≥75 years | 0.99 (0.72–1.36) | 0.936 | 0.56 (0.41–0.76) | <0.0001 |
| Low educational level | 1.34 (0.97–1.85) | 0.080 | 0.91 (0.66–1.25) | 0.569 |
| Multimorbidity (≥2 diseases) | 1.34 (0.89–2.02) | 0.166 | 1.20 (0.79–1.81) | 0.387 |
| Hypertension | 0.52 (0.29–0.94) | 0.031 | 1.38 (0.81–2.36) | 0.234 |
| Type 2 diabetes mellitus | 1.29 (0.46–3.58) | 0.629 | 1.04 (0.35–3.07) | 0.948 |
| Covariate | OR (CI 95%) | p-value |
|---|---|---|
| Residence (rural) | 0.83 (0.55–1.24) | 0.360 |
| Sex (woman) | 1.62 (1.02–2.58) | 0.041 |
| Age ≥75 years | 0.65 (0.45–0.94) | 0.023 |
| Low educational level | 0.93 (0.63–1.37) | 0.702 |
| Multimorbidity (≥2 diseases) | 1.55 (0.93–2.60) | 0.094 |
| Hypertension | 0.57 (0.31–1.06) | 0.075 |
| Type 2 diabetes mellitus | 0.89 (0.31–2.55) | 0.826 |
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