Background: Registered nurses (RNs) working in Primary Health Care (PHC) settings in South Africa (SA) are experiencing burnout, and it is a growing concern. Early recognition of signs and support methods is vital for effective prevention strategies. If burnout is left unattended, it will negatively impact the well-being of RNs, and patient care will be compromised. Aim: The study aims to explore early detection of burnout and the available support systems for RNs working in PHC settings in a district based in Gauteng Province, South Africa.Objectives: To identify signs and symptoms of burnout among RNs, examine contributing organisational stressors, assess awareness and recognition of burnout, and explore existing mitigation and support strategies. Methods: The study followed an exploratory qualitative design approach. In-depth face-to-face semi-structured interviews were conducted with 17 participants, with data saturation reached after the 12 interviews. The data was coded and analyzed using thematic content analysis, which included five interrelated steps. Results: The results revealed that RNs are experiencing burnout. Four main themes emerged: manifestations of burnout among registered nurses, organizational stressors, poor recognition and awareness of burnout, and mitigation and organizational support. Conclusion: Burnout is a reality among RNs in a District in Gauteng Province, South Africa, and it is often neglected until symptoms worsen. Promoting early detection through screening RNs and providing burnout education and awareness, coupled with organizational changes, will benefit RNs' well-being and the quality of care for patients.