Selected Proteins Involved in the Neuropathology of ASD as the Candidates for Fluid Biomarkers

Autism spectrum disorder (ASD) is a neurological condition with an increasingly high incidence rate due to more effective diagnostic tools. The symptoms of ASD vary widely, making it difficult to detect. It represents a spectrum of alterations ranging from mild indications to severe impairments. Given this clinical presentation, each patient should be treated on an individual basis. Nevertheless, certain neuropathological changes are common, although the background of this disorder remains still unknown. Therefore, some research aimed at better understanding the pathology of the neurological alterations in ASD, as well as the possibilities for early diagnosis and treatment of this disorder, is urgently needed. This study presents the results of the studies on some selected proteins such as Tau protein, NFL, BDNF as well as IGF-1 that appear to be the best protein candidates for better understanding the causes of autism, as well as for use as fluid biomarkers in diagnosis and monitoring of ASD.