The nontrivial zeros of the Riemann zeta function are parameterized by the spectral variable \( s\in\mathbb{C} \), and the isomonodromic deformation parameter t of the Painlevé III equation of type \( D_6 \) is connected to s by \( t=s(1-s) \), which maps the critical line \( \Re(s)=\frac12 \) to the positive real ray \( t\in[\frac14,\infty) \). Any de Branges realization of the Riemann Hypothesis within this framework requires four explicit conditions: (C1) geometric feasibility ---the positive lambda-length slice of the \( \mathrm{PIII}_{D_6} \) character variety defines a real form of the wild Stokes and monodromy data; (C2) global positivity---the Riemann--Hilbert jump matrices yield a Herglotz Weyl--Titchmarsh function; (C3) embedding compatibility---the functional equation involution \( s\mapsto 1-\bar{s} \) preserves the positive slice; and (C4) analytic regularity---the tau-function composed with \( t=s(1-s) \) is entire of finite order after gauge removal. We prove all four conditions unconditionally. For (C1), an explicit birational map \( \Phi \) expresses all Stokes multipliers as positive monomials in the lambda-lengths. For (C2), the Painlevé/gauge theory correspondence identifies the \( \mathrm{PIII}_{D_6} \) oper with a Schrödinger operator whose real coefficients force \( \Im m(\lambda,t)>0 \) via a Wronskian argument; isomonodromic uniqueness and Remling's inverse theorem complete the proof. For (C4), integrality of the local exponent \( \alpha\in\mathbb{Z}_{\ge0} \) is the precise criterion, satisfied on an explicit sublocus of the positive slice. With all four conditions established, the Riemann Hypothesis reduces to the Bridge Conjecture alone. We test the direct form of the Bridge Conjecture---the identification \( E_{D_6}(s)=C\,\xi(s) \)---and show it fails for all constant monodromy phases and for all Dirichlet L-functions, because the tau-zero counting \( \mathcal{N}_{D_6}(T)\sim 2T/\pi \) lacks the \( \log T \) factor of the Riemann--von Mangoldt law. This leads to the identification of \( E_{D_6}(s) \) as a new explicit element of the Hermite--Biehler class \( \mathcal{HB}(1/2) \), whose canonical form is the isomonodromic cosine \( F(s)=\cos(2\sqrt{s(1-s)}) \). We prove that \( F\in\mathcal{HB}(1/2) \) is entire of order 1, satisfies \( F(s)=F(1-s) \), has all zeros on \( \Re s=\frac12 \) at \( \gamma_n=\sqrt{(2n-1)^2\pi^2-4}\,/\,4 \), with asymptotic spacing \( \pi/2 \) identified as the WKB semiclassical level spacing of the \( \mathrm{PIII}_{D_6} \) oper arising from the Seiberg--Witten period \( a_{D_6}(t)=2\sqrt{t} \). A four-tier falsifiability diagnostic and the character \( \chi_4 \) scorecard are presented.