Knowledge and Attitudes toward Mpox among Medical Students in Bulgaria and North Macedonia: A Cross-Sectional Study during the 2022 Global Outbreak

Mpox re-emerged as a global public health concern during the 2022 international out-break, underscoring the necessity of preparedness among future healthcare professionals. This study sought to evaluate knowledge and attitudes toward Mpox among medical students in Bulgaria and North Macedonia. A cross-sectional, online survey was con-ducted from May to September 2022 among undergraduates attending medical universi-ties in both nations. The questionnaire evaluated demographic variables, knowledge of Mpox, and attitudes toward conspiracy theories associated with the emerging infectious disease. A total of 1,313 students participated, with a mean age of 22.6 ± 4.4 years and 63.7% being female. While 56.3% of respondents were familiar with Mpox, hardly 16.9% indicated having received formal or specialized information regarding the disease. Signif-icant information deficiencies were observed: merely 38.1% accurately acknowledged that antibiotics are ineffective against Mpox, and 25.0% were knowledgeable of the availability of vaccinations for prophylaxis. Common misconceptions regarding transmission and resemblances to other vesicular illnesses were prevalent. Attitudinal research indicated significant uncertainty and partial support for conspiracy theories concerning new path-ogens. The findings reveal inadequate readiness among prospective healthcare workers and highlight the necessity to enhance medical education on emerging infectious illnesses to facilitate early detection, risk communication, and epidemic preparedness in South-eastern Europe.