In this paper, the leakage inductances influences of integrated-transformer are investigated for an input-series flyback converter, in which each input-series circuit is based on the single-switch flyback topology. First, configuration of this converter is introduced, and a novel multiple inductors coupling model is proposed for its flyback integrated-transformer. Second, operational process of this converter is analyzed considering the leakage inductances between primary and secondary windings of its integrated-transformer. Third, influences of these leakage inductances are analyzed, on this basis, the essential design considerations of flyback integrated-transformer are summarized. Finally, an experimental prototype of this input-series converter is built, based on which, the analysis is verified by the experimental comparisons among three flyback integrated-transformers with various windings layouts.