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Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction - A Review of Randomized Controlled Trials in Last 10 Years

Submitted:

04 February 2025

Posted:

05 February 2025

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Abstract
Homocysteine is an amino acid derived from methionine, metabolized via vitamin B6 (pyridoxine)- and vitamin B12 (cobalamin)-dependent pathways. Supplementation of B vitamins has been shown to effectively reduce plasma homocysteine levels. Previous research has also demonstrated an association between lower plasma homocysteine levels and decreased risk of myocardial infarction, stroke and venous thromboembolism. However, it remains inconclusive if supplementation of B vitamins is associated with risk reduction in thromboembolic events and confers clinical benefits. This article aims to review clinical trials in the last ten years to determine the effects of B vitamin supplementation in plasma homocysteine lowering, and evaluate its impact on reducing the risk of arterial and venous thromboembolism.
Keywords: 
vitamin B; homocysteine; thrombotic risk; randomized controlled trials; thrombosis; pyridoxine; folic acid; folate; cobalamin
Subject: 
Medicine and Pharmacology  -   Clinical Medicine
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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