How Noise-Induced Hearing Loss Affects Hypertension: Pathophysiology and Prevention

Verena Scheper; Thomas Lenarz; Stavros Stavrakis; Carola Förster

doi:10.20944/preprints202410.0653.v1

Submitted:

08 October 2024

Posted:

10 October 2024

You are already at the latest version

Abstract

More than 5% of the global population suffers from disabling hearing loss, primarily sensorineural hearing loss (SNHL). SNHL is often caused by factors such as vascular disorders, viral infections, ototoxic drugs, systemic inflammation, age-related labyrinthine membrane degeneration, and noise-induced hearing loss (NIHL). NIHL, in particular, leads to changes in blood-labyrinth-barrier (BLB) physiology, increased permeability, and various cardiovascular health issues, including hypertension, diabetes, neurological disorders, and adverse reproductive outcomes: Research has connected an elevated risk of hypertension with loud noise. The endocrine and autonomic nervous systems are also linked to arousal following an acute exposure to loud sounds. As a preventive option for both NIHL and hypertension as sequela of noise trauma, we present the transcutaneous vagus nerve stimulation (taVNS). taVNS may be appropriate to prevent NIHL-associated hypertension, as it typically reduces blood pressure and improves heart rate variability. On the other hand, normalizing cerebral blood flow preserves cochlear homeostasis, which is maintained by the BLB.The paper provides a comprehensive overview of NIHL pathophysiology and the impact of noise on auditory structures and function. Our research focuses on the auditory structures and functions affected by noise, such as the strial BLB, as well as the autonomic changes caused by NIHL, specifically the emergence of NIHL-associated hypertension as a primary comorbidity. We describe the clear link between taVNS use and increased HRV and slower progression of chronic hypertension, and we propose it as a cutting-edge preventive option for both conditions.

Keywords:

Noise-induced hearing loss (NIHL)

;

blood-labyrinth-barrier (BLB)

;

hypertension

;

transcutaneaous vagus stimulation (tVNS)

;

cardiovascular disease

;

prevention

Subject:

Medicine and Pharmacology - Cardiac and Cardiovascular Systems

1. Introduction

Noise-Induced Hearing Loss

According to the 2020 World report on hearing by the World Health Organization [1], disabling hearing loss affects over 5% of the global population, with SNHL being a major contributor. SNHL can result from various factors, including vascular disorders, viral infections, ototoxic drugs, systemic inflammation, labyrinthine membrane degeneration, and NIHL. Prolonged exposure to loud sounds, typically above 85 dB, leads to permanent hearing loss and related health issues.

NIHL is a very prominent type of SNHL, specifically pronounced among adults.

In Two different conditions have to be separated: acute acoustic trauma caused by e.g., blast exposure and hearing loss as a consequence of chronic noise exposure. this review, we focus on NIHL based on ongoing noise trauma. It is the result of ongoing high levels of occupational, military, and recreational noise to name the most common triggers [2]. Specifically, young people are at risk of NIHL development due to the increasing use of headphones to enjoy music. Individuals exposed to sound higher than 85 dB for more than 5 hours weekly are prone to suffer permanent hearing damage over time, while adverse, while importantly, the relationship between hearing loss caused by occupational noise and the risk of the different adverse health effects varies, among other things, with the level of frequency [2]. Taken together, the World Health Organization reports that in sum loud sound exposure is acknowledged to potentially cause NIHL in more than 600 million people worldwide [1].

This paper will provide an overview of NIHL, its pathophysiology, its impact on membrane transporters, channels, and BLB structures, and the auditory and non-auditory effects of noise impacting on the cardiovascular system. We offer timely solutions for its treatment as well as of its major comorbidity, hypertension, providing potential solutions to this widespread issue. Specifically, As we develop innovative means of prevention and treatment, we take advantage of recent advances in neuromodulation and vector-based approaches, which offer hope for countering autonomic imbalances and overcoming biological barriers like the BLB.

2. Auditory Structures and Functions Impacted by Noise

Ongoing acoustic exposure can induce a level of damage that is accompanied by temporary threshold shift (TTS) or impairments accompanied by permanent threshold shift (PTS). Despite previous assumptions, recurrent episodes of TTS may not be related to PTS in the long term, as it was believed in previous years, because the two conditions are characterized by different pathogenetic mechanisms (for review see [3]).

2.1. Mechanisms of TTS

TTS is defined by, at least, 10 dB of threshold elevation in one or more frequencies between 2 and 4 kHz. This threshold shift may reach 50 dB [4]. TTS lasts from minutes to days depending on the pathophysiology of the damage. Low-level TTS is mediated by ion channels that are activated by extracellular ATP [5]. The relevant ATP receptor P2RX2 is a nonselective cation channel, expressed in cochlear hair cells (HCs) and epithelial cells lining the scala media. Noise stimulates local ATP release in the cochlea, the ATP opens the channels, which then shunt endocochlear current away from the HC transduction channel [3]).

Higher levels of TTS (up to 50 dB) are due to additional mechanisms such as uncoupling of the outer HC stereocilia from the tectorial membrane [6] and swelling of the afferent endings underneath the inner HCs, suggestive of excitotoxicity due to the release of excessive glutamate from overstimulated HCs [3]).

Other evidence suggests that damaging levels of noise lead to metabolic overstimulation and subsequent generation of free radical species [7,8]. Reactive oxygen species (ROS) and reactive nitrogen species (RNS).

2.2. Mechanisms of PTS

When exposed to a sufficiently loud and long-lasting noise, the cochlea’s ability to recover gets overwhelmed, leading to irreversible hearing loss. This kind of hearing loss is mainly linked to damage and loss of cochlear HCs, but damage to neurons and other parts of the cochlea can also contribute to PTS [3]. This damage can directly disrupt the stereocilia [9], which diminishes or completely stops their function. In severe cases, the damage can even affect the overall structure of the sensory part of the cochlea, disrupting HC and their support cells. This kind of damage can also create a connection between two fluid-filled areas in the cochlea, endolymph, and perilymph, allowing excessive levels of potassium to reach the basal poles of remaining intact HCs, leading to their death. However, damaging levels of noise begin well below the threshold of such frank mechanical damage. The majority of NIHL is caused by damage to HC through biochemical processes that occur within the cells themselves via ROS production as in the case of TTS.

2.3. TTS, PTS, and Free Radical Impact

The cascade of events initiated by ROS induction entails lipid peroxidation within the cochlea, thereby giving rise to the generation of highly noxious metabolic byproducts. While the products of lipid peroxidation alone can induce apoptosis, lipid peroxidation byproducts possessing vasoactive properties, such as isoprostanes, may potentially contribute to a diminished blood supply to the cochlea [10]. Noise-induced ischemia and subsequent reperfusion might further potentiate the generation of ROS in a positive feedback loop [3]. Furthermore, ROS-mediated mechanisms encompass the provocation of inflammatory responses, including the production of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) which themselves hold the capability to inflict damage upon the cochlear structure and function [11].

3. The Role of Stria Vascularis in NIHL

Recent investigations highlight the role of the stria vascularis (SV), located in the lateral wall of the cochlea, in the pathogenesis of NIHL [12]. A previous study highlighted that loud noise exposure could lead to a reduced vessel diameter, while concomitantly an increase in vascular permeability in the SV [13], and increased macromolecular transport was observed that could decrease the endocochlear potential (EP) [12]. However, the underlying mechanism remains unclear and might however be potentially related to the formation of excess ROS, RNS, release of pro-inflammatory cytokines, and ultimately excitotoxicity, as detailed above (com. 1.1.1. - 1.1.3.).

The SV is derived from the spiral modiolar artery supplying the organ of Corti (OoC) and primary auditory neurons (Figure 1) and is mainly composed of marginal, intermediate, and basal cells and the endothelial cells forming the so-called strial BLB (Figure 2).

Anatomically, the blood supply to the cochlea comes from the common cochlear artery, which divides into the spiral modiolar artery and the vestibulocochlear artery. The spiral modiolar artery supplies the apical turns of the cochlea, and the cochlear branch of the vestibulocochlear artery supplies the basal turns of the cochlea (Figure 1). The spiral modiolar artery supplies the OoC and primary auditory neurons of the modiolus and forms the capillaries of the spiral ligament and stria vascularis in the cochlear lateral wall. Strial capillaries are nonfenestrated with tight junctions between adjacent endothelial cells and a decreasing rate of entry into perilymph from blood by compounds of increasing molecular weight [14,15], forming a barrier that separates intrastrial fluids from blood, the BLB. Historically, the concept of the strial BLB in the inner ear originated from the observed difference in the chemical composition of blood and inner ear fluids (Figure 2).

Significant functions of the SV are to i) generate the endocochlear potential (EP), which is essential for an audition, ii) secretion of endolymph, and iii) maintain cochlear homeostasis by controlling ion homeostasis and substance exchanges between blood and the interstitial space in the cochlea at the level of the endothelial BLB (Figure 2).

4. The Blood-Labyrinth Barrier (BLB) – Functional Contribution to SNHL Pathologies

The strial BLB is a highly specialized network of capillaries tightly controlling the permeability of the capillaries and controlling macromolecular exchange between blood and the interstitial space in the cochlea [16,17]. The strial BLB thus maintains cochlear homeostasis and protects the cochlea from blood-borne potentially ototoxic endobiotics and xenobiotics.

The strial BLB is fundamentally similar to the blood-brain barrier (BBB) that separates brain interstitial fluid from blood (Figure 1): the BLB separates the inner ear fluid compartments (perilymph and endolymph) from capillaries of the vasculature and is composed of vascular endothelial cells coupled together by tight junctions. The BLB is critical for the maintenance of the inner ear fluid ionic homeostasis and for the prevention of the entry of deleterious substances into the inner ear. Recent studies have implicated loss of the integrity of the BLB in several inner ear pathologies including acoustic trauma, infection, ototoxin-induced hearing loss, and age-related hearing loss (presbycusis).

In this connection, loud sounds affect almost all cochlear cell types and induce inflammation and drug-induced cochleotoxicity. Acoustic trauma [18] pertains prominently to the several external and intrinsic factors that can profoundly modulate the permeability of the BLB [19], increasing its permeability and subsequent uptake of drugs indirectly by inducing inflammation and degeneration of sensory cells and auditory neurons (Figure 3).

Different disease states in comorbidity to NIHL can alter BLB physiology and increase its permeability through inflammation and oxidative stress: cochlear inflammation [11]. caused by acoustic trauma in turn contributes to the degeneration of cochlear sensory cells.

5. Spectrum of NIHL-Associated Disorders

Repeated overexposure to noise at or above 85 dB can cause permanent hearing loss, tinnitus, and difficulty in understanding speech in noise. It is also associated with cardiovascular disease, depression, balance problems, cognitive dysfunction (children), and lower-income [20]. In case untreated, NIHL has a high propensity to establish fatigue, communication difficulty, social isolation, and stress [21]. Damage to the SV in NIHL has progressively been recognized to be at the root of many common disorders and syndromic diseases accompanied with NIHL, many of which are cerebro- and cardiovascular disease: Accumulation of noise-induced damage to the inner ear is a key trigger of age-related hearing loss and cognitive decline [16], tinnitus and even diminished learning and cognitive abilities in children and adolescents [22] (Figure 4).

Chronic, subjective tinnitus, an auditory phantom sensation in the absence of physical stimuli, can be triggered by a variety of causes that may act synergistically [23]. However, scientists generally agree that tinnitus is generated within the brain in response to a reduction of auditory nerve fiber input from the cochlea to the brain. By far the major cause of cochlear damage resulting in deafferentiation is environmental noise overexposure [23,24]. Of note, besides noise-induced tinnitus [23] about 64% of patients with NIHL exhibited comorbidities, and the most common condition was hypertension.

6. Noise above the Permissive Threshold May Beget Autonomic Changes and Hypertension

There was a higher incidence of hypertension among patients with sudden sensorineural hearing loss (SSNHL) when compared to 54,946 matched controls [25]. There is biological plausibility that sustained noise exposure may result in health effects related to stress after acute noise exposure (Figure 5). Specifically, there appears to be an increased risk of hypertension associated with noise-induced high-frequency hearing loss, and the risk varies by age and work experience [25]: the presence of elevated noise exposure was associated with an increased risk of hypertension in a meta-analysis of 32 studies involving 264,678 participants. A significant dose-response relationship between noise exposure and hypertension was found [26].

7. A New Method for Preventing and Treating NIHL and Hypertension Using Vagus Nerve Stimulation

It has been consistently demonstrated that noise, be it environmental, leisure-derived, or occupational, above the permissible limit of 85 dB leads to autonomic changes and alterations in blood pressure [27,28,29]. In the following section we provide an incentive for NIHL’s future clinical translation for prevention and therapy by Vagus nerve stimulation (VNS): The use of VNS has become increasingly popular as a prevention and treatment method for a number of clinical conditions, such as migraines, tinnitus, and depression [30,31]. Robust approaches have been developed in response to growing scientific knowledge about the vagus nerve (VNS) and insights into the anatomy/conduction and function of the VN. The cutaneous distribution of afferent VN fibers in the auricle, or the auricular branch of the VN (ABVN), is used in the taVNS application. By stimulating the ABVN in the tragus, tVNS is a simple, non-invasive emergency treatment that has become widely used worldwide. It has few side effects [32]. Recent research on animals addressed tVNS and hypertension. The outcome of this research presents the taVNS as a preventive option for both pathologies, NIHL and hypertension, since these studies clearly show a relationship between tVNS application and an increased HRV and a slower progression of chronic hypertension without altering fibrosis in hypertensive rats.

While there is still the possibility that NIHL may lead to dampening of the vagus nerve, one can imply from the positive results of tVNS treatment on tinnitus conditions obtained so far, that stimulation of the vagus nerve may may have a positive effect on NIHL as well. Hence, vagus nerve stimulation (VNS) may be an emerging therapeutic option to treat and possibly even prevent NIHL. VNS is increasingly being used to treat conditions such as epilepsy, depression, and chronic inflammation, as well as an aid to rehabilitation, and also as a technique for cognitive improvement [31]. Nonetheless, VNS requires implantation of a device using an invasive technique, which may not be acceptable by many patients [33]. These limitations led to the development of transcutaneous VNS (tVNS), by stimulating the auricular branch of the vagus nerve at the tragus or the concha of the ear [32]. This technique is associated with minimal risk, thus opening up the possibility for novel applications even in healthy individuals (Figure 6).

taVNS in combination with tone therapy has been demonstrated to be an efficient and safe method not show significant side effects. Several preclinical and small cohort clinical studies help foster this assumption to combine taVNS with tones to improve auditory processing, e.g., in patients with tinnitus or possibly NIHL [31]. Towards acquired hearing loss following noise trauma, one could refer to reports in animals showing that VNS paired with specific tones improved tinnitus in follow-up and was sufficient to reverse the abnormal plasticity of the primary auditory cortex shown to be associated with tinnitus [34] . On the other hand, pilot clinical studies highlight the feasibility and safety of VNS paired with tones in patients with moderate to severe chronic tinnitus [35]. These studies combined with reported beneficial effects on hypertension [36,37,38,39] and heart failure [40,41], with minimal, if any, side effects, give sufficient evidence that studies on this topic ought to be extended and moved forward.

Of note, non-invasive vagus nerve stimulation reduces disruption of the BBB which is intimately related to the BLB in a rat model of ischemic stroke [42], so that a transferable effect to the strial BLB following NIHL can be assumed.

8. Conclusion

Loud sounds, typically above 85 decibels (dB), can lead to permanent hearing loss and hypertension as the most prominent health consequences. As sequelae of noise trauma and stress, we present NIHL and its primary comorbidity, hypertension, and investigate novel preventive measures. A substantial amount of evidence is presented in this paper to demonstrate that taVNS is suitable for developing future NIHL and hypertension treatments, thus providing possible solutions to this widespread issue.

Author Contributions

Conceptualization, C.Y.F. and T.L.; methodology, C.Y.F., S.St. and V.S..; validation, T.L., S.St. and C.Y.F.; formal analysis, C.Y.F., V.S. and S.St.; writing—original draft preparation, V.S., C.Y.F., S.St. and T.L..; review and editing, V.S., C.Y.F., and S.St.; supervision, funding acquisition and project administration C.Y.F.; All authors have read and agreed to the published version of the manuscript.

Funding

This work was supported by grants DFG Fo 315/5-1 and investment contribution of foundation Forschung hilft to CYF.

Institutional Review Board Statement

none

Informed Consent Statement

none

Data Availability Statement

N/A

Acknowledgments

Special thanks are extended to Dr. J. Engert and Dr. K. Rak, University hospital Würzburg for helpful discussions.

Conflicts of Interest

The authors declare no conflict of interest.

Abbreviations

ARHL: age-related hearing loss; BBB: blood-brain barrier; BLB: blood-labyrinth-barrier; EP: endocochlear potential; HC: hair cell; LA: labyrinth artery; NIHL: noise-induced hearing loss; OoC: organ of corti; PTS: permanent threshold shift; RM: Reissner membrane; ScV: scala vestibule; SL: spiral ligament; SMA: spiral modular artery; SM: scala media; SNHL: sensorineural hearing loss; SSNHL: sudden sensorineural hearing loss; ST: scala tympani; SV: stria vascularis; taVNS: transcutaneous auricular vagus nerve stimulation; TTS: temporary threshold shift; tVNS: transcutaneous vagus nerve stimulation;

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Figure 1. Structure and blood supply of the cochlea. The spiral modiolar artery supplies the OoC of the modiolus and forms the capillaries of the spiral ligament and stria vascularis in the cochlear lateral wall. SMA = spiral modular artery, SL = spiral ligament, SV = Stria vascularis, OoC = organ of corti, ScV = Scala vestibuli, SM = Scala media, ST = Scala tympani, RM = Reissner membrane, LA = labyrinthinth artery.

Figure 2. Cross section of one cochlea turn and rough structure of the stria vascularis, SV. Structural and functional damage to the SV mediated by noise trauma, specifically to the endothelial blood-labyrinth barrier, BLB, causes hearing loss, but the underlying mechanisms remain mostly unclear.

Figure 3. SNHL - functional contribution of the BLB. Pathogenes leading SNHL include vascular disorders, viral infections, noise trauma, ototoxic drug exposure, and age-related degeneration of the labyrinthine membrane.

Figure 4. auditory and non-auditory effects of noise overexposure. Noise is in everyday life and can lead to both auditory and non-auditory adverse health effects, including hearing loss, tinnitus, neuropsychiatric effects, and cognitive impairment; and secondary to triggered circuit conditions like e.g., cardiovascular and neurodegenerative disease, and hypertension.

Figure 5. stress-response elicited by elevated noise. Pathways of elevated noise action leading to hypertension through mental stress, autonomic nervous system change sympathetic imbalance, anxiety, and neurohormonal mechanisms. The elevated risk factors noise exposure because of a primary rudimentary stress reaction, mediated either by activation of the sympathetic nervous system or the hypothalamic–pituitary–adrenal (HPA) axis resulting in fight/ flight response, anxiety, and hypertension.

Figure 6. Transcutaneous vagus nerve stimulation targeting the auricular branch of the vagus nerve: taVNS. Non-invasive taVNS delivery systems rely on the cutaneous distribution of vagal fibers, at the external ear (auricular branch of the vagus nerve) [43] as detailed in the insert. Red circles in the main image and clamps in the insert, respectively, represent the best anatomical sites for A active left tragus stimulation by the taVNS device, B blue circles and clamps represent sham control stimulation sites, respectively.

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