Version 1
: Received: 21 May 2024 / Approved: 23 May 2024 / Online: 23 May 2024 (16:47:59 CEST)
How to cite:
Momha, R. Design and Synthesis of Novels Alkylglycerols based Acetylenic Derivatives from 1,10-Decanediol and Stearolic Acid Analogues of Bioactive Ether Lipids. Preprints2024, 2024051576. https://doi.org/10.20944/preprints202405.1576.v1
Momha, R. Design and Synthesis of Novels Alkylglycerols based Acetylenic Derivatives from 1,10-Decanediol and Stearolic Acid Analogues of Bioactive Ether Lipids. Preprints 2024, 2024051576. https://doi.org/10.20944/preprints202405.1576.v1
Momha, R. Design and Synthesis of Novels Alkylglycerols based Acetylenic Derivatives from 1,10-Decanediol and Stearolic Acid Analogues of Bioactive Ether Lipids. Preprints2024, 2024051576. https://doi.org/10.20944/preprints202405.1576.v1
APA Style
Momha, R. (2024). Design and Synthesis of Novels Alkylglycerols based Acetylenic Derivatives from 1,10-Decanediol and Stearolic Acid Analogues of Bioactive Ether Lipids. Preprints. https://doi.org/10.20944/preprints202405.1576.v1
Chicago/Turabian Style
Momha, R. 2024 "Design and Synthesis of Novels Alkylglycerols based Acetylenic Derivatives from 1,10-Decanediol and Stearolic Acid Analogues of Bioactive Ether Lipids" Preprints. https://doi.org/10.20944/preprints202405.1576.v1
Abstract
Resistance to the existing drugs and increasing numbers of diseases result in identifying new drug candidates with new forms of activity. Marine sources of alkylglycerols such as the liver oil Shark (SLO) mixture of certain species or rat fish (elasmobranch fishes) contain high levels of these compounds as a mixture of few species varying by length and unsaturation or saturation of the alkyl chain. They have multiple biological activities such as hematopoiesis stimulation, lowering radiotherapy-induced injuries, reducing tumor growth and improving vaccination efficiency. The synthesis of two Alkylglycerols (AKGs) containing at least one alkyne moiety in the alkyl chain has been reported. In this work, we describe the synthesis of others unknown AKGs based alkyne 1-O-(hexadec-11’-ynyl)-sn-glycerol 4 and 1-O-(octadec-9’-ynyl)-sn-glycerol 5 as analogues of bioactive ether lipids found in the SLO mixture.
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
