Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility

Juliano Flávio Rubatino Rodrigues
* ORCID logo ,
Lívia Peregrino Rodrigues
,
Kelly Cristina Atalaia da Silva
,
Fernando Victor Martins Rubatino
ORCID logo ,
Hannes Fischer
,
Franciany Cunha Peregrino Rodrigues
,
Edward Goulart Junior
,
Pedro Marco Karan Barbosa
,
Spencer Luiz Marques Payão
,
Moacir Fernandes de Godoy
ORCID logo ,
Gerardo Maria de Araújo Filho
Version 1 : Received: 16 May 2024 / Approved: 17 May 2024 / Online: 17 May 2024 (11:36:39 CEST)

How to cite: Rodrigues, J. F. R.; Rodrigues, L. P.; Atalaia da Silva, K. C.; Rubatino, F. V. M.; Fischer, H.; Rodrigues, F. C. P.; Goulart Junior, E.; Barbosa, P. M. K.; Payão, S. L. M.; Godoy, M. F. D.; de Araújo Filho, G. M. A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility. Preprints 2024, 2024051144. https://doi.org/10.20944/preprints202405.1144.v1 Rodrigues, J. F. R.; Rodrigues, L. P.; Atalaia da Silva, K. C.; Rubatino, F. V. M.; Fischer, H.; Rodrigues, F. C. P.; Goulart Junior, E.; Barbosa, P. M. K.; Payão, S. L. M.; Godoy, M. F. D.; de Araújo Filho, G. M. A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility. Preprints 2024, 2024051144. https://doi.org/10.20944/preprints202405.1144.v1

Abstract

Background: There have been reports of numerous risk factors for Alzheimer's disease. Although widely investigated, some points during the evolution of the disease have been obscure. One of them is a great frustration with therapeutic expectations. Why has there been an increase in suicidal behavior in treatments with anti-beta-amyloid drugs? Interpersonal stress is one of the factors that may be connecting Alzheimer's disease to suicide. Method: To observe possible associations between Alzheimer's disease and suicide, two validated questionnaires were selected. We recruited 20 elderly patients over 65 years old to observe the feasibility of further research using these instruments. The study was considered viable if all participants showed no difficulty in understanding the questions and completed both questionnaires in less than 30 minutes with a tendency to homogeneity. A description of the statistical data obtained was made. Results: All participants adequately understood the questions and completed the questionnaires in less than 30 minutes. In 10% of the sample, suicide attempts occurred throughout their lives. The average age of respondents was 75 years old. The QoSL Pareto diagram demonstrated a large concentration. The data demonstrated homogeneity. Conclusions: The application of the questionnaires in a sample suitable for carrying out analytical statistics was demonstrated. We have two great tools to try to understand the possible association between Alzheimer's disease and suicide.

Keywords

Alzheimer’s Disease; suicide; questionnaire; pilot study; feasibility

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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