Ooi, H.; Furukawa, A.; Takeuchi, M.; Koriyama, Y. Toxic Advanced Glycation End-Products Inhibited Axonal Elongation Mediated by β-Tubulin Aggregation in Mice Optic Nerve. Preprints2024, 2024050316. https://doi.org/10.20944/preprints202405.0316.v1
APA Style
Ooi, H., Furukawa, A., Takeuchi, M., & Koriyama, Y. (2024). Toxic Advanced Glycation End-Products Inhibited Axonal Elongation Mediated by β-Tubulin Aggregation in Mice Optic Nerve. Preprints. https://doi.org/10.20944/preprints202405.0316.v1
Chicago/Turabian Style
Ooi, H., Masayoshi Takeuchi and Yoshiki Koriyama. 2024 "Toxic Advanced Glycation End-Products Inhibited Axonal Elongation Mediated by β-Tubulin Aggregation in Mice Optic Nerve" Preprints. https://doi.org/10.20944/preprints202405.0316.v1
Abstract
Advanced glycation end-products (AGEs) form through non-enzymatic glycation of various proteins. Optic nerve degeneration is a frequent complication of diabetes, and retinal AGEs accumulation is strongly linked to diabetic retinopathy development. Type 2 diabetes mellitus (T2DM) is a major risk factor for Alzheimer's disease (AD), with patients often exhibiting optic axon degeneration in the nerve fiber layer. Notably, a gap exists in our understanding of how AGEs contribute to neuronal degeneration in the optic nerve within the context of both diabetes and AD. Our previous work demonstrated that glyceraldehyde (GA)-derived toxic advanced glycation end-products (TAGE) disrupt neurite outgrowth through TAGE-β-tubulin aggregation and tau phosphorylation in neural cultures. In this study, we further illustrated GA-induced suppression of optic nerve axonal elongation via abnormal β-tubulin aggregation in mouse retinas. Elucidating this optic nerve degeneration mechanism holds promise for bridging the knowledge gap regarding vision loss associated with DM and AD.
Keywords
toxic advanced glycation-end products; glyceraldehyde; axonal elongation; β-tubulin; tau
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
