Version 1
: Received: 30 April 2024 / Approved: 30 April 2024 / Online: 1 May 2024 (07:29:18 CEST)
How to cite:
Viebahn-Haensler, R.; León Fernández, O. Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.. Preprints2024, 2024050029. https://doi.org/10.20944/preprints202405.0029.v1
Viebahn-Haensler, R.; León Fernández, O. Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.. Preprints 2024, 2024050029. https://doi.org/10.20944/preprints202405.0029.v1
Viebahn-Haensler, R.; León Fernández, O. Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.. Preprints2024, 2024050029. https://doi.org/10.20944/preprints202405.0029.v1
APA Style
Viebahn-Haensler, R., & León Fernández, O. (2024). Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review.. Preprints. https://doi.org/10.20944/preprints202405.0029.v1
Chicago/Turabian Style
Viebahn-Haensler, R. and Olga León Fernández. 2024 "Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone. A Systematic Review." Preprints. https://doi.org/10.20944/preprints202405.0029.v1
Abstract
Our hypothesis that controlled ozone applications interfere into the redox balance of the biological organism (first published in 1998 with a preclinical trial on protecting the liver from CCl4 intoxication), has been verified over the last 2 decades in reactive oxygen species (ROS)-induced mitochondrial pathologies, such as rheumatoid arthritis, osteoarthritis, aging processes, diabetes-2 and in prevention of intoxications. Low-dose ozone acts as a redox bioregulator: The restoration of the disturbed redox balance is comprehensible in a number of preclinical and clinical studies by a remarkable increase of the antioxidant repair markers, here mainly shown as glutathione increase and a reduction in oxidative stress markers, mainly malondialdehyde. The mechanism of action is shown, relevant data are displayed, evaluated and comprehensively discussed: The repair side of the equilibrium increases by 21% up to 140% compared to the non-ozone treated groups and depending on the indication; the stress markers are simultaneously reduced, the redox system regains its balance.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
