Orthobiologic Management Options for Degenerative Disc Disease

Cezar Augusto Alves de Oliveira; Bernardo Scaldini Oliveira; Rafael Theodoro; Joshua Wang; Gabriel Silva Santos; Bruno Lima Rodrigues; Izair Jefthé Rodrigues; Daniel de Moraes Ferreira Jorge; Madhan Jeyaraman; Peter Albert Everts; Annu Navani; José Fábio Lana

doi:10.20944/preprints202405.0012.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202405.0012.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Orthobiologic Management Options for Degenerative Disc Disease

Cezar Augusto Alves de Oliveira

Bernardo Scaldini Oliveira

^* ,

Izair Jefthé Rodrigues

Daniel de Moraes Ferreira Jorge

^* ,

Version 1 : Received: 29 April 2024 / Approved: 30 April 2024 / Online: 1 May 2024 (07:43:01 CEST)

How to cite: de Oliveira, C. A. A.; Oliveira, B. S.; Theodoro, R.; Wang, J.; Santos, G. S.; Rodrigues, B. L.; Rodrigues, I. J.; Jorge, D. D. M. F.; Jeyaraman, M.; Everts, P. A.; Navani, A.; Lana, J. F. Orthobiologic Management Options for Degenerative Disc Disease. Preprints 2024, 2024050012. https://doi.org/10.20944/preprints202405.0012.v1 de Oliveira, C. A. A.; Oliveira, B. S.; Theodoro, R.; Wang, J.; Santos, G. S.; Rodrigues, B. L.; Rodrigues, I. J.; Jorge, D. D. M. F.; Jeyaraman, M.; Everts, P. A.; Navani, A.; Lana, J. F. Orthobiologic Management Options for Degenerative Disc Disease. Preprints 2024, 2024050012. https://doi.org/10.20944/preprints202405.0012.v1

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MDPI and ACS Style

de Oliveira, C. A. A.; Oliveira, B. S.; Theodoro, R.; Wang, J.; Santos, G. S.; Rodrigues, B. L.; Rodrigues, I. J.; Jorge, D. D. M. F.; Jeyaraman, M.; Everts, P. A.; Navani, A.; Lana, J. F. Orthobiologic Management Options for Degenerative Disc Disease. Preprints 2024, 2024050012. https://doi.org/10.20944/preprints202405.0012.v1

APA Style

de Oliveira, C. A. A., Oliveira, B. S., Theodoro, R., Wang, J., Santos, G. S., Rodrigues, B. L., Rodrigues, I. J., Jorge, D. D. M. F., Jeyaraman, M., Everts, P. A., Navani, A., & Lana, J. F. (2024). Orthobiologic Management Options for Degenerative Disc Disease. Preprints. https://doi.org/10.20944/preprints202405.0012.v1

Chicago/Turabian Style

de Oliveira, C. A. A., Annu Navani and José Fábio Lana. 2024 "Orthobiologic Management Options for Degenerative Disc Disease" Preprints. https://doi.org/10.20944/preprints202405.0012.v1

Abstract

Degenerative disc disease (DDD) is a pervasive condition that limits quality of life and burdens economies. Traditional pharmacological treatments aimed at slowing degeneration are ineffective in the long-term. Orthobiologics, regenerative agents derived from the patient’s own tissue, are a promising emerging therapy for degenerative disc disease. This review first outlines the pathophysiology of degenerative disc disease, highlighting the limitations of existing treatments and explores the orthobiologic tools for treating degenerative disc disease (platelet-rich plasma, mesenchymal stem cells). Their history in regenerative medicine is outlined, demonstrating how in vitro evidence informed preclinical animal studies on their efficacy in treating degenerative disc disease. Finally, clinical trials utilizing these treatment options are reviewed and directions for future research are outlined. Although the current clinical evidence available is limited to propagate their routine clinical usage the field holds immense potential in the management of DDD. There is room for these treatments to be optimized for effective consistent clinical outcomes in DDD.

Keywords

disc disease; orthobiologics; inflammation; orthopedics; regenerative medicine

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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