Version 1
: Received: 14 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (14:06:02 CEST)
How to cite:
Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) Regulates PD-L1 Expression
in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Preprints2024, 2024040990. https://doi.org/10.20944/preprints202404.0990.v1
Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) Regulates PD-L1 Expression
in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Preprints 2024, 2024040990. https://doi.org/10.20944/preprints202404.0990.v1
Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) Regulates PD-L1 Expression
in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Preprints2024, 2024040990. https://doi.org/10.20944/preprints202404.0990.v1
APA Style
Bhattacharyya, S., O-Sullivan, I., & Tobacman, J.K. (2024). N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) Regulates PD-L1 Expression
in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Preprints. https://doi.org/10.20944/preprints202404.0990.v1
Chicago/Turabian Style
Bhattacharyya, S., Insug O-Sullivan and Joanne Kramer Tobacman. 2024 "N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) Regulates PD-L1 Expression
in Melanoma by an HDAC3-Mediated Epigenetic Mechanism" Preprints. https://doi.org/10.20944/preprints202404.0990.v1
Abstract
Effects of the enzyme N-acetylgalactosamine-4-sulfatase (Arylsulfatase B, ARSB), which removes the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate, on the expression of PD-L1 were determined and the underlying mechanism of PD-L1 expression elucidated. Initial experiments in human melanoma cells (A375) showed PD-L1 expression increased from 357 ± 31 to 796 ± 50 pg/mg protein (p
Biology and Life Sciences, Biochemistry and Molecular Biology
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