Version 1
: Received: 14 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (14:17:59 CEST)
How to cite:
Borrás Cuartero, J.; Torres Gorriz, M.C.; Stein Coronado, C.I.; Germán Sánchez, A.; Pesántez Méndez, C.G.; Latorre Ibáñez, M.D.; Enrique, E. The Increasing Role of the Allergist in the Management of Infusion Reactions at the Oncology Day Hospital. Preprints2024, 2024040978. https://doi.org/10.20944/preprints202404.0978.v1
Borrás Cuartero, J.; Torres Gorriz, M.C.; Stein Coronado, C.I.; Germán Sánchez, A.; Pesántez Méndez, C.G.; Latorre Ibáñez, M.D.; Enrique, E. The Increasing Role of the Allergist in the Management of Infusion Reactions at the Oncology Day Hospital. Preprints 2024, 2024040978. https://doi.org/10.20944/preprints202404.0978.v1
Borrás Cuartero, J.; Torres Gorriz, M.C.; Stein Coronado, C.I.; Germán Sánchez, A.; Pesántez Méndez, C.G.; Latorre Ibáñez, M.D.; Enrique, E. The Increasing Role of the Allergist in the Management of Infusion Reactions at the Oncology Day Hospital. Preprints2024, 2024040978. https://doi.org/10.20944/preprints202404.0978.v1
APA Style
Borrás Cuartero, J., Torres Gorriz, M.C., Stein Coronado, C.I., Germán Sánchez, A., Pesántez Méndez, C.G., Latorre Ibáñez, M.D., & Enrique, E. (2024). The Increasing Role of the Allergist in the Management of Infusion Reactions at the Oncology Day Hospital. Preprints. https://doi.org/10.20944/preprints202404.0978.v1
Chicago/Turabian Style
Borrás Cuartero, J., Maria Dolores Latorre Ibáñez and Ernesto Enrique. 2024 "The Increasing Role of the Allergist in the Management of Infusion Reactions at the Oncology Day Hospital" Preprints. https://doi.org/10.20944/preprints202404.0978.v1
Abstract
Same-day desensitization (SDD) is a procedure in which desensitization to the drug suspected of causing the hypersensitivity reaction (HR) is performed on the same day as the patient's reaction. In rapid drug desensitization (RDD), desensitization to the suspected drug is performed after an allergological study. The aim of the study was to analyze the diagnostic capacity of the allergist in Oncology Day Hospital (ODH) to establish the phenotype of the HR, in the context of SDD, based exclusively on clinical biomarkers. This is a study of patients treated with desensitization on the same day they had a HR. Later an allergological study (clinical history, skin test, risk assessment, serological biomarkers, drug provocation test if applicable) was performed prior to the following administrations. A total of 35 successful SDDs were performed. A high concordance (91.5% of patients) was found between the phenotype suspected by the allergist after the initial assessment of the patient prior to SDD and the final phenotype after subsequent allergological study performed in the Allergy Department. The presence of the allergist at the ODH allows, in addition to initial treatment according to phenotype, desensitization on the day of the reaction. This will lead to personalized and precision allergology.
Keywords
drug allergy; rapid drug desensitization; same‐day desensitization; chemotherapy allergy; personalized & precision medicine
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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