Radical Cyclization-initiated Difunctionalization Reactions of Alkenes and Alkynes

Sanjun Zhi; Xiaoming Ma; Wei Zhang

doi:10.20944/preprints202404.0865.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 12 April 2024 / Approved: 12 April 2024 / Online: 15 April 2024 (08:01:52 CEST)

Radical reactions are powerful in the synthesis of diverse molecular scaffolds bearing functional groups. In pervious review articles, we have presented 1,2-difunctionalizations, remote 1,3-, 1,4-, 1,5-, 1,6- and 1,7-difunctionalizations, and addition followed by cyclization reactions. Presents in this paper are radical cyclization followed by the second functionalization reactions. The second functionalization could be realized by atom transfer reactions, radical or transition metal-assisted coupling reactions, and reactions with neutral molecules, cationic and anionic species.

radical; difunctionalization; atom transfer; cyclization; coupling; addition

Chemistry and Materials Science, Organic Chemistry

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Radical Cyclization-initiated Difunctionalization Reactions of Alkenes and Alkynes

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