Version 1
: Received: 10 April 2024 / Approved: 10 April 2024 / Online: 11 April 2024 (07:57:14 CEST)
How to cite:
Kim, H.; Liu, Z. LSD2 is an Epigenetic Player in Multiple Types of Cancer and Beyond. Preprints2024, 2024040749. https://doi.org/10.20944/preprints202404.0749.v1
Kim, H.; Liu, Z. LSD2 is an Epigenetic Player in Multiple Types of Cancer and Beyond. Preprints 2024, 2024040749. https://doi.org/10.20944/preprints202404.0749.v1
Kim, H.; Liu, Z. LSD2 is an Epigenetic Player in Multiple Types of Cancer and Beyond. Preprints2024, 2024040749. https://doi.org/10.20944/preprints202404.0749.v1
APA Style
Kim, H., & Liu, Z. (2024). LSD2 is an Epigenetic Player in Multiple Types of Cancer and Beyond. Preprints. https://doi.org/10.20944/preprints202404.0749.v1
Chicago/Turabian Style
Kim, H. and Zifei Liu. 2024 "LSD2 is an Epigenetic Player in Multiple Types of Cancer and Beyond" Preprints. https://doi.org/10.20944/preprints202404.0749.v1
Abstract
Histone demethylases, enzymes responsible for removing methyl groups from histone proteins, have emerged as critical players in regulating gene expression and chromatin dynamics, thereby influencing various cellular processes. LSD2 and LSD1 have attracted considerable interest among these demethylases because of their associations with cancer. However, while LSD1 has received significant attention, LSD2 has not been recognized to the same extent. In this study, we conduct a comprehensive comparison between LSD2 and LSD1, with a focus on exploring LSD2's implications. While both share structural similarities, LSD2 possesses unique features. Functionally, LSD2 shows diverse roles, particularly in cancer, with tissue-dependent roles. Additionally, LSD2 extends beyond histone demethylation, impacting DNA methylation and DNA damage repair pathways. This study underscores the distinct roles of LSD2, providing insights into their contributions to cancer and other cellular processes.
Keywords
LSD2; KDM1B; AOF1; LSD1; KDM1A; histone demethylase; cancer; DNA repair
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
