PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity
Version 1
: Received: 1 April 2024 / Approved: 2 April 2024 / Online: 2 April 2024 (15:15:49 CEST)
How to cite:
Hall, J.R.; Petersen, M.; O’Bryant, S.E. The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity. Preprints2024, 2024040223. https://doi.org/10.20944/preprints202404.0223.v1
Hall, J.R.; Petersen, M.; O’Bryant, S.E. The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity. Preprints 2024, 2024040223. https://doi.org/10.20944/preprints202404.0223.v1
Hall, J.R.; Petersen, M.; O’Bryant, S.E. The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity. Preprints2024, 2024040223. https://doi.org/10.20944/preprints202404.0223.v1
APA Style
Hall, J.R., Petersen, M., & O’Bryant, S.E. (2024). The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity. Preprints. https://doi.org/10.20944/preprints202404.0223.v1
Chicago/Turabian Style
Hall, J.R., Melissa Petersen and Sid E. O’Bryant. 2024 "The Relationship of Plasma Biomarkers of Alzheimer’s Disease and Neuropsychological Test Performance in Older Adults with Unimpaired Cognition: The Impact of Ethnicity" Preprints. https://doi.org/10.20944/preprints202404.0223.v1
Abstract
There has been significant increase of studies investigating plasma biomarkers of Alzheimer’s and their relationship to cognitive functioning. The impact of ethnicity on this relationship has not been extensively studied. The current research investigated the relationship between the plasma biomarkers of total tau, Aβ40, Aβ42 and NfL and neuropsychological test performance in a bi-ethnic sample of cognitively unimpaired, older community dwelling adults. The 1326 cognitively unimpaired participants drawn from The Health & Aging Brain Study – Health Disparities (HABS-HD) study included 765 Mexican American participants and 860 non-Hispanic White participants with complete plasma biomarkers and neuropsychological testing. Plasma samples were assayed using Simoa technology. Significant differences in concentrations were found for all of the plasma biomarkers. NHWs had significantly higher levels of each of the biomarkers with a lower Aβ42/ Aβ40. With none of the biomarkers related to performance on any of the neuropsychological tests. For MAs, Aβ40 was the only biomarker that was significantly related to neuropsychological test performance. Aβ40 levels were negatively related to performance on Trails A, Trails B and Digit Symbol Substitution. Results suggest that the relationship of these biomarkers to cognitive functioning is impacted by ethnicity and may be domain specific.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
