Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Vital Cruvinel Ferreira-Filho
ORCID logo ,
Beatriz Morais
,
Bruno J. C. Vieira
ORCID logo ,
João Carlos Waerenborgh
ORCID logo ,
Maria João Carmezim
ORCID logo ,
Csilla Noémi Tóth
,
Sandra Même
,
Sara Lacerda
,
Daniel Jaque
,
Celia Tavares de Sousa
,
Maria Paula Cabral Campello
* ,
Laura Cristina Jesus Pereira
* ORCID logo
Version 1 : Received: 26 March 2024 / Approved: 26 March 2024 / Online: 28 March 2024 (12:20:09 CET)

A peer-reviewed article of this Preprint also exists.

Ferreira-Filho, V.C.; Morais, B.; Vieira, B.J.C.; Waerenborgh, J.C.; Carmezim, M.J.; Tóth, C.N.; Même, S.; Lacerda, S.; Jaque, D.; Sousa, C.T.; Campello, M.P.C.; Pereira, L.C.J. Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile. Molecules 2024, 29, 1824. Ferreira-Filho, V.C.; Morais, B.; Vieira, B.J.C.; Waerenborgh, J.C.; Carmezim, M.J.; Tóth, C.N.; Même, S.; Lacerda, S.; Jaque, D.; Sousa, C.T.; Campello, M.P.C.; Pereira, L.C.J. Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile. Molecules 2024, 29, 1824.

Abstract

This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11-13% of Fe present in magnetite, while samples obtained from MpH have higher content, of 33%-45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.

Keywords

superparamagnetism; iron oxides nanoparticles; gold nanoparticles; gadolinium; hyperthermia; magnetic resonance imaging

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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