Version 1
: Received: 22 March 2024 / Approved: 25 March 2024 / Online: 26 March 2024 (11:45:15 CET)
How to cite:
Eldaghayes, I.; Rothwell, L.; Skinner, M.; Kaiser, P. Recombinant Fowlpox Virus fpIBD1 in Chicken’s Skin: Persistence and the Local Immune Response at the Site of Inoculation. Preprints2024, 2024031589. https://doi.org/10.20944/preprints202403.1589.v1
Eldaghayes, I.; Rothwell, L.; Skinner, M.; Kaiser, P. Recombinant Fowlpox Virus fpIBD1 in Chicken’s Skin: Persistence and the Local Immune Response at the Site of Inoculation. Preprints 2024, 2024031589. https://doi.org/10.20944/preprints202403.1589.v1
Eldaghayes, I.; Rothwell, L.; Skinner, M.; Kaiser, P. Recombinant Fowlpox Virus fpIBD1 in Chicken’s Skin: Persistence and the Local Immune Response at the Site of Inoculation. Preprints2024, 2024031589. https://doi.org/10.20944/preprints202403.1589.v1
APA Style
Eldaghayes, I., Rothwell, L., Skinner, M., & Kaiser, P. (2024). Recombinant Fowlpox Virus fpIBD1 in Chicken’s Skin: Persistence and the Local Immune Response at the Site of Inoculation. Preprints. https://doi.org/10.20944/preprints202403.1589.v1
Chicago/Turabian Style
Eldaghayes, I., Michael Skinner and Pete Kaiser. 2024 "Recombinant Fowlpox Virus fpIBD1 in Chicken’s Skin: Persistence and the Local Immune Response at the Site of Inoculation" Preprints. https://doi.org/10.20944/preprints202403.1589.v1
Abstract
Fowlpox virus (FPV) has been used as a vector for many years. To date, surprisingly, very little data exist on the persistence of fowlpox vaccines in chicken tissues, or what kind of immune cells respond to the vaccination at the site of inoculation. Although both humoral and cellular mediated immunity (CMI) play a part in overall immunity against FPV, little is known regarding the cell-mediated immune responses to FPV infection. The main aim of this paper was to measure persistence of the recombinant fowlpox vaccine in the skin tissues following vaccination. The results showed that the recombinant FPVs do not persist for long, and are cleared by 6 days post-vaccination (dpv). The response of immune cells (macrophages, B cells, CD4+ and CD8+ T cells) that infiltrating the site of vaccination was estimated.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
