Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Covid19 and Pregnancy: Infected Mothers and Premature Babies?

Rita Franco
,
Federica Perelli
* ,
Vitalba Gallitelli
,
Marco Parasiliti
,
Annalisa Vidiri
ORCID logo ,
Giovanna Palomba
,
Marta Bisanti
,
Amelia Spanò
,
Adele Silvagni
,
Alessandra Lopez
ORCID logo ,
Giuseppe Gullo
ORCID logo ,
Gaspare Cucinella
,
Anna Franca Cavaliere
Version 1 : Received: 21 March 2024 / Approved: 21 March 2024 / Online: 22 March 2024 (11:23:27 CET)

How to cite: Franco, R.; Perelli, F.; Gallitelli, V.; Parasiliti, M.; Vidiri, A.; Palomba, G.; Bisanti, M.; Spanò, A.; Silvagni, A.; Lopez, A.; Gullo, G.; Cucinella, G.; Cavaliere, A.F. Covid19 and Pregnancy: Infected Mothers and Premature Babies?. Preprints 2024, 2024031341. https://doi.org/10.20944/preprints202403.1341.v1 Franco, R.; Perelli, F.; Gallitelli, V.; Parasiliti, M.; Vidiri, A.; Palomba, G.; Bisanti, M.; Spanò, A.; Silvagni, A.; Lopez, A.; Gullo, G.; Cucinella, G.; Cavaliere, A.F. Covid19 and Pregnancy: Infected Mothers and Premature Babies?. Preprints 2024, 2024031341. https://doi.org/10.20944/preprints202403.1341.v1

Abstract

Introduction: The emergency of the SARS-CoV-2 virus spread and its subsequent global pan-demic have raised significant concerns regarding its impact on pregnancy outcomes. This review aims to summarize the emerging data on the risk of preterm delivery in pregnant women infected with SARS-CoV-2. Materials and Methods: A systematic search was conducted from March 2020 to December 2023 using PubMed, following PRISMA guidelines. Studies correlating maternal COVID-19 infection with preterm birth were included. Results: Thirteen studies were analyzed, indicating a higher incidence of preterm birth in SARS-CoV-2 positive pregnant women compared to controls. The average incidence rate of pre-term birth in infected patients was 18.5%, with a median of 12.75%, while non infected women showed an average incidence of preterm birth of 10% with a median of 8.2%. Discussion: Studies suggest an association between SARS-CoV-2 infection during pregnancy and increased risk of preterm birth and cesarean section. Severity of symptoms and underlying comorbidities further elevate this risk. Notably, infections during the third trimester pose the highest risk of preterm birth. Conclusion: Preventing SARS-CoV-2 infection during pregnancy is crucial to mitigate adverse obstetric outcomes. Close monitoring and tailored interventions for infected pregnant women, particularly those in later trimesters and with comorbidities, are imperative to reduce the risk of preterm birth and improve maternal-fetal outcomes.

Keywords

SARS-CoV-2; COVID-19; preterm birth; pregnancy outcomes; obstetric outcomes

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.