PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Drug Delivery Applications
Version 1
: Received: 12 March 2024 / Approved: 13 March 2024 / Online: 13 March 2024 (16:05:00 CET)
How to cite:
Villanueva-Lumbreras, J.A.; Rodriguez, C.; Aguilar, M.R.; Aviles-Arnaut, H.; Cordell, G.A.; Rodriguez-Garcia, A. Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Drug Delivery Applications. Preprints2024, 2024030783. https://doi.org/10.20944/preprints202403.0783.v1
Villanueva-Lumbreras, J.A.; Rodriguez, C.; Aguilar, M.R.; Aviles-Arnaut, H.; Cordell, G.A.; Rodriguez-Garcia, A. Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Drug Delivery Applications. Preprints 2024, 2024030783. https://doi.org/10.20944/preprints202403.0783.v1
Villanueva-Lumbreras, J.A.; Rodriguez, C.; Aguilar, M.R.; Aviles-Arnaut, H.; Cordell, G.A.; Rodriguez-Garcia, A. Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Drug Delivery Applications. Preprints2024, 2024030783. https://doi.org/10.20944/preprints202403.0783.v1
APA Style
Villanueva-Lumbreras, J.A., Rodriguez, C., Aguilar, M.R., Aviles-Arnaut, H., Cordell, G.A., & Rodriguez-Garcia, A. (2024). Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Drug Delivery Applications. Preprints. https://doi.org/10.20944/preprints202403.0783.v1
Chicago/Turabian Style
Villanueva-Lumbreras, J.A., Geoffrey A. Cordell and Aida Rodriguez-Garcia. 2024 "Nanofibrous ε-Polycaprolactone Matrices Containing Nano-Hydroxyapatite and Humulus lupulus L. Extract: Physicochemical and Biological Characterization for Drug Delivery Applications" Preprints. https://doi.org/10.20944/preprints202403.0783.v1
Abstract
Oral bone defects occur as a result of trauma, cancer, infections, periodontal diseases, and caries. Autogenic and allogenic grafts are the gold standard used to treat and regenerate damaged or defective bone segments. However, these materials do not possess the antimicrobial properties necessary to inhibit the invasion of the numerous deleterious pathogens present in the oral microbiota.
In the present study poly(ε-caprolactone) (PCL), nano-hydroxyapatite (nHAp), and a commercial extract of Humulus lupulus L. (hops) were electrospun into polymeric matrices to assess their po-tential for drug delivery and bone regeneration.
The fabricated matrices were analyzed by scanning electron microscopy (SEM), tensile analysis, thermogravimetric analysis (TGA), FT-IR assay, and in vitro hydrolytic degradation. The antimi-crobial properties were evaluated against the oral pathogens Streptococcus mutans, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans. The cytocompatibility was proved by the MTT assay. SEM analysis proved the nanostructured matrices have suitable fiber size.
The present research provides new information about the interaction of natural compounds with ceramic and polymeric biomaterials. The hop extract and other natural or synthetic medicinal agents can be effectively loaded into PCL fibers and has the potential to be used in biomedical applications.
Keywords
poly(-caprolactone); electrospinning; nano-hydroxyapatite; Humulus lupulus; hops; drug delivery system; bone regeneration
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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