Version 1
: Received: 7 March 2024 / Approved: 8 March 2024 / Online: 8 March 2024 (06:25:27 CET)
How to cite:
Brezdeń, K.; Waszkielewicz, A.M. Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea. Preprints2024, 2024030494. https://doi.org/10.20944/preprints202403.0494.v1
Brezdeń, K.; Waszkielewicz, A.M. Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea. Preprints 2024, 2024030494. https://doi.org/10.20944/preprints202403.0494.v1
Brezdeń, K.; Waszkielewicz, A.M. Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea. Preprints2024, 2024030494. https://doi.org/10.20944/preprints202403.0494.v1
APA Style
Brezdeń, K., & Waszkielewicz, A.M. (2024). Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea. Preprints. https://doi.org/10.20944/preprints202403.0494.v1
Chicago/Turabian Style
Brezdeń, K. and Anna M. Waszkielewicz. 2024 "Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea" Preprints. https://doi.org/10.20944/preprints202403.0494.v1
Abstract
Xanthone derivatives, a class of natural compounds abundantly found in plants such as mangosteen (Garcinia mangostana) and certain herbs, have garnered substantial interest due to their diverse pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer activities. Recent investigations have unveiled their potential as modulators of enzymatic activity, prompting exploration into their effects on hyaluronidase-mediated HA degradation, and their effects in topical treatment of telangiectasia and rosacea. Telangiectasia and rosacea are common dermatological conditions characterized by chronic skin inflammation, vascular abnormalities, and visible blood vessels, resulting in significant cosmetic concerns and impaired quality of life for affected individuals. This review aims to provide a comprehensive overview of the current understanding regarding the interplay between mechanisms of action by which xanthone derivatives exert their therapeutic effects, including the inhibition of pro-inflammatory cytokines, modulation of oxidative stress pathways, and regulation of vascular endothelial growth factors. Furthermore, we will discuss the implications of harnessing xanthone derivatives as therapeutic agents for mitigating vascular dysfunction and its associated pathologies, thereby offering insights into future research directions and therapeutic strategies in the field of vascular biology.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
