Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

NHC-Catalyzed Cross-Coupling of Aldehydes for C(sp2)−O Bond Formation

Version 1 : Received: 7 March 2024 / Approved: 7 March 2024 / Online: 7 March 2024 (11:09:09 CET)

A peer-reviewed article of this Preprint also exists.

Yamaoka, Y.; Miyabe, H. NHC-Catalyzed Reaction of Aldehydes for C(sp2)–O Bond Formation. Catalysts 2024, 14, 219. Yamaoka, Y.; Miyabe, H. NHC-Catalyzed Reaction of Aldehydes for C(sp2)–O Bond Formation. Catalysts 2024, 14, 219.

Abstract

In the past few decades, N-heterocyclic carbenes (NHCs) open the new field of organocatalysis in synthetic organic chemistry. This review highlights the dramatic progress in the NHC-catalyzed C−O bond formation based on the activation of aldehyde C(sp2)−H bonds. The oxidative and redox transformations for the synthesis of various molecules with structural diversity and complexity are summarized. Furthermore, new methods and strategies for NHC catalysis are emerging continuously; thus, cooperative catalysis with Brønsted acid, hydrogen-bonding catalyst, transition-metal catalyst, and photocatalyst is also described.

Keywords

N-heterocyclic carbenes; organocatalysis; C−O bond formation; aldehyde; cooperative catalysis

Subject

Chemistry and Materials Science, Organic Chemistry

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