The Sda Carbohydrate Antigen and Its Biosynthetic Enzyme B4GALNT2 in Health and Disease.

Martina Duca; Nadia Malagolini; Fabio Dall’Olio

doi:10.20944/preprints202402.1754.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 29 February 2024 / Approved: 29 February 2024 / Online: 29 February 2024 (17:01:39 CET)

The carbohydrate antigen Sda is expressed on cells and secretions of the vast majority of Caucasians. The epitope is formed by a terminal GalNAc residue β4-linked to a α3-sialylated galactose. Different carbohydrate chains N- or O-linked to glycoproteins can be terminated by this epitope. The final step of Sda biosynthesis is catalyzed by the GalNAc transferase B4GALNT2. In this review, we will discuss the multifaceted aspects of B4GALNT2/Sda biology. In particular, we will see its implications in fertility and pregnancy, in susceptibility to infectious diseases, in chronic kidney diseases and in Duchene muscular dystrophy. In particular, we will show its regulation and prognostic implications in cancer.

Sda antigen; B4GALNT2; uromodulin; Tamm- Horsfall glycoproteins; influenza virus; Duchene muscular dystrophy.

Biology and Life Sciences, Biochemistry and Molecular Biology

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The Sda Carbohydrate Antigen and Its Biosynthetic Enzyme B4GALNT2 in Health and Disease.

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