Version 1
: Received: 21 February 2024 / Approved: 23 February 2024 / Online: 25 February 2024 (23:35:08 CET)
How to cite:
Szczerbinska, A.; Kasztelan-Szczerbinska, B.; Rycyk-Bojarzynska, A.; Cichoz-Lach, H. Hereditary Hemochromatosis – How Not to Overlook and Properly Manage “Iron People”- a Critical Overview. Preprints2024, 2024021362. https://doi.org/10.20944/preprints202402.1362.v1
Szczerbinska, A.; Kasztelan-Szczerbinska, B.; Rycyk-Bojarzynska, A.; Cichoz-Lach, H. Hereditary Hemochromatosis – How Not to Overlook and Properly Manage “Iron People”- a Critical Overview. Preprints 2024, 2024021362. https://doi.org/10.20944/preprints202402.1362.v1
Szczerbinska, A.; Kasztelan-Szczerbinska, B.; Rycyk-Bojarzynska, A.; Cichoz-Lach, H. Hereditary Hemochromatosis – How Not to Overlook and Properly Manage “Iron People”- a Critical Overview. Preprints2024, 2024021362. https://doi.org/10.20944/preprints202402.1362.v1
APA Style
Szczerbinska, A., Kasztelan-Szczerbinska, B., Rycyk-Bojarzynska, A., & Cichoz-Lach, H. (2024). Hereditary Hemochromatosis – How Not to Overlook and Properly Manage “Iron People”- a Critical Overview. Preprints. https://doi.org/10.20944/preprints202402.1362.v1
Chicago/Turabian Style
Szczerbinska, A., Anna Rycyk-Bojarzynska and Halina Cichoz-Lach. 2024 "Hereditary Hemochromatosis – How Not to Overlook and Properly Manage “Iron People”- a Critical Overview" Preprints. https://doi.org/10.20944/preprints202402.1362.v1
Abstract
Hereditary hemochromatosis (HH) is the main genetic cause of iron overload and is regarded as metal-related human toxicosis. HH may result from HFE and non-HFE gene mutations causing hepcidin deficiency or hepcidin resistance. The disorder has a high biochemical penetrance, but a low clinical prevalence. Unfortunately, the majority of patients with HH remain undiagnosed at their disease-curable stage. The main aim of HH therapy is to prevent iron overload in the early-phase disease and elimination of excess iron from the body by phlebotomy in its late stage. Raising global awareness of HH among health professionals, their training to pay attention to early HH signs and symptoms, and strict patient monitoring are critical management strategies for preventing treatment delays, upgrading its efficacy, and improving patient prognosis.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
