Version 1
: Received: 21 February 2024 / Approved: 22 February 2024 / Online: 22 February 2024 (15:24:51 CET)
Version 2
: Received: 23 February 2024 / Approved: 23 February 2024 / Online: 23 February 2024 (13:25:01 CET)
How to cite:
Ji, K.; Zeng, X.; Wei, J.; Zhang, L.; Hao, L.; Fan, M.; Chen, X. The SGLT2 Inhibitors Empagliflozin Alleviate Renal Fibrosis by Inhibiting CTGF-Mediated Epithelial-Mesenchymal Transition in Diabetic Sprague-Dawley (SD) Rats. Preprints2024, 2024021288. https://doi.org/10.20944/preprints202402.1288.v1
Ji, K.; Zeng, X.; Wei, J.; Zhang, L.; Hao, L.; Fan, M.; Chen, X. The SGLT2 Inhibitors Empagliflozin Alleviate Renal Fibrosis by Inhibiting CTGF-Mediated Epithelial-Mesenchymal Transition in Diabetic Sprague-Dawley (SD) Rats. Preprints 2024, 2024021288. https://doi.org/10.20944/preprints202402.1288.v1
Ji, K.; Zeng, X.; Wei, J.; Zhang, L.; Hao, L.; Fan, M.; Chen, X. The SGLT2 Inhibitors Empagliflozin Alleviate Renal Fibrosis by Inhibiting CTGF-Mediated Epithelial-Mesenchymal Transition in Diabetic Sprague-Dawley (SD) Rats. Preprints2024, 2024021288. https://doi.org/10.20944/preprints202402.1288.v1
APA Style
Ji, K., Zeng, X., Wei, J., Zhang, L., Hao, L., Fan, M., & Chen, X. (2024). The SGLT2 Inhibitors Empagliflozin Alleviate Renal Fibrosis by Inhibiting CTGF-Mediated Epithelial-Mesenchymal Transition in Diabetic Sprague-Dawley (SD) Rats. Preprints. https://doi.org/10.20944/preprints202402.1288.v1
Chicago/Turabian Style
Ji, K., Mingliang Fan and Xiaomin Chen. 2024 "The SGLT2 Inhibitors Empagliflozin Alleviate Renal Fibrosis by Inhibiting CTGF-Mediated Epithelial-Mesenchymal Transition in Diabetic Sprague-Dawley (SD) Rats" Preprints. https://doi.org/10.20944/preprints202402.1288.v1
Abstract
Objective: Aims to investigate the effects of empagliflozin (EMPA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, on renal fibrosis in male diabetic Sprague-Dawley (SD) rat model. Methods: Streptozotocin(STZ) were injected to establish diabetes model, EMPA (10 mg/kg·d) or normal saline (NS) were administered for four weeks. The changes in renal fibrosis-related biomarkers, include vimentin (VIM), collagen types I(Col-I), collagen types III(Col-III), fibroblast-specific protein 1(FSP-1), connective tissue growth factor (CTGF), fibronectin (FN) were evaluated. Renal pathology, serum glucose levels and urinary protein excretion were also assessed. Results: Biomarkers of renal fibrosis were significantly reduced in the EMPA group compared to those in the NS group after 4-week treatment, including VIM (519.84±83.37 vs. 663.27±91.84 ng/ml, P
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
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