Disclosing Morbidity and Mortality by Routine Blood Analyses of the Emergency Room in Omicron COVID-19 Patients. A Retrospective Study

Eqrem Rusi; Fiorenza Pennacchia; Wael Abu Ruqa; Maria Antonella Zingaropoli; Patrizia Pasculli; Giuseppina Talarico; Giuseppe Bruno; Christian Barbato; Antonio Minni; Luigi Tarani; Gioacchino Galardo; Francesco Pugliese; Marco Lucarelli; Maria Rosa Ciardi; Luigi Meucci; Giampiero Ferraguti; Marco Fiore

doi:10.20944/preprints202402.1279.v1

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preprints.org > medicine and pharmacology > epidemiology and infectious diseases > doi: 10.20944/preprints202402.1279.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Disclosing Morbidity and Mortality by Routine Blood Analyses of the Emergency Room in Omicron COVID-19 Patients. A Retrospective Study

Eqrem Rusi

Fiorenza Pennacchia

Wael Abu Ruqa

Maria Antonella Zingaropoli

Version 1 : Received: 21 February 2024 / Approved: 22 February 2024 / Online: 22 February 2024 (08:46:28 CET)

A peer-reviewed article of this Preprint also exists.

Rusi, E.; Pennacchia, F.; Ruqa, W.A.; Zingaropoli, M.A.; Pasculli, P.; Talarico, G.; Bruno, G.; Barbato, C.; Minni, A.; Tarani, L.; Galardo, G.; Pugliese, F.; Lucarelli, M.; Ciardi, M.R.; Meucci, L.; Ferraguti, G.; Fiore, M. Blood Count and Renal Functionality Assessments in the Emergency Section Disclose Morbidity and Mortality in Omicron COVID-19 Patients: A Retrospective Study. Clin. Pract. 2024, 14, 685-702. Rusi, E.; Pennacchia, F.; Ruqa, W.A.; Zingaropoli, M.A.; Pasculli, P.; Talarico, G.; Bruno, G.; Barbato, C.; Minni, A.; Tarani, L.; Galardo, G.; Pugliese, F.; Lucarelli, M.; Ciardi, M.R.; Meucci, L.; Ferraguti, G.; Fiore, M. Blood Count and Renal Functionality Assessments in the Emergency Section Disclose Morbidity and Mortality in Omicron COVID-19 Patients: A Retrospective Study. Clin. Pract. 2024, 14, 685-702.

Abstract

SARS-CoV-2 is the Coronavirus responsible for the COVID-19 pandemic. Even though we are no more in a pandemic situation, people are getting infected some of them needing hospitalization, and a few of them die. Methods: We did a retrospective study including 445 patients who accessed the Emergency Section of Policlinico Umberto I, Rome, Italy, where they had routine blood exams. In this study, we concentrated on the complete blood count, creatinine, and azotemia. The data was analyzed using ANOVA, Spearman correlation, and ROC analysis. They were divided into four groups based on their outcome: (1) the emergency group (patients with mild forms who were quickly discharged); (2) the hospital ward group (patients who after admission to the emergency section were hospitalized in a COVID-19 ward); (3) the intensive care unit (ICU) group (patients that after the admission in the emergency section required intensive assistance); (4) the deceased group (patients that after the admission in the emergency section had a fatal outcome). Results: We found significant changes for creatinine, azotemia, hematocrit, mean corpuscular hemoglobin concentration, basophils, monocytes, red blood cell distribution width, hemoglobin, hematocrit, and red blood cell numbers by ANOVA according to their outcomes, particularly for the deceased group. Also, we found outcome correlations for eosinophils, hemoglobin, hematocrit, mean corpuscular hemoglobin concentration, lymphocyte, neutrophil, platelet, and red blood cell number and red blood cell distribution width. Conclusions: This study discloses an association between “classical” routine blood biomarkers and the severity of outcomes in Omicron patients.

Keywords

SARS-Cov-2; Mortality; Morbidity; Biomarkers; Variant; Blood Analyses; Omicron

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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