Review
Version 1
Preserved in Portico This version is not peer-reviewed
Synthesis and Biological Activities of Some Metal Complexes of Peptides: A Review
Version 1
: Received: 18 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (11:19:42 CET)
A peer-reviewed article of this Preprint also exists.
Marinova, P.; Tamahkyarova, K. Synthesis and Biological Activities of Some Metal Complexes of Peptides: A Review. BioTech 2024, 13, 9. Marinova, P.; Tamahkyarova, K. Synthesis and Biological Activities of Some Metal Complexes of Peptides: A Review. BioTech 2024, 13, 9.
Abstract
Peptides, both natural and synthetic, are well suited for a wide range of purposes and offer versa-tile applications in different fields such as biocatalysts, injectable hydrogels, tumor treatment, and drug delivery. The rising prominence of therapeutic peptides encompasses anticancer, antiviral, antimicrobial, and anti-neurodegenerative properties. The metals Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn, and Mo are ten of the twenty elements that are considered essential for life. Crucial for under-standing the biological role of metals is the exploration of metal-bound proteins and peptides. Aside from essential metals, there are other, non-essential metals that also interact biologically, exhibiting either therapeutic or toxic effects. Irregularities in metal binding contribute to diseases like Alzheimer’s, neurodegenerative disorders, Wilson's, and Menkes disease. Certain metal com-plexes have potential applications as radiopharmaceuticals. The examination of these complexes was done by preforming UV-Vis, IR, EPR, NMR spectroscopy, and X-ray analysis.
Keywords
peptides; metal complexes; biological activities
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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