Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Daiken Satake; Manabu Natsumeda; Kaishi Satomi; Mari Tada; Taro Sato; Noritaka Okubo; Keita Kawabe; Haruhiko Takahashi; Yoshihiro Tsukamoto; Masayasu Okada; Masakazu Sano; Haruko Iwabuchi; Nao Shibata; Masaru Imamura; Chihaya Imai; Hirokazu Takami; Koichi Ichimura; Ryo Nishikawa; Hajime Umezu; Akiyoshi Kakita; Makoto Oishi

doi:10.20944/preprints202402.0935.v1

A peer-reviewed article of this Preprint also exists.

Satake, D.; Natsumeda, M.; Satomi, K.; Tada, M.; Sato, T.; Okubo, N.; Kawabe, K.; Takahashi, H.; Tsukamoto, Y.; Okada, M.; Sano, M.; Iwabuchi, H.; Shibata, N.; Imamura, M.; Imai, C.; Takami, H.; Ichimura, K.; Nishikawa, R.; Umezu, H.; Kakita, A.; Oishi, M. Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features. Curr. Oncol. 2024, 31, 1831-1838. Satake, D.; Natsumeda, M.; Satomi, K.; Tada, M.; Sato, T.; Okubo, N.; Kawabe, K.; Takahashi, H.; Tsukamoto, Y.; Okada, M.; Sano, M.; Iwabuchi, H.; Shibata, N.; Imamura, M.; Imai, C.; Takami, H.; Ichimura, K.; Nishikawa, R.; Umezu, H.; Kakita, A.; Oishi, M. Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features. Curr. Oncol. 2024, 31, 1831-1838.

Abstract

Molecular analysis of growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.

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Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features

Abstract

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