Fernández, S.; Arnáiz, V.; Rufo, D.; Arroyo, Y. Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications. Mar. Drugs2024, 22, 126.
Fernández, S.; Arnáiz, V.; Rufo, D.; Arroyo, Y. Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications. Mar. Drugs 2024, 22, 126.
Fernández, S.; Arnáiz, V.; Rufo, D.; Arroyo, Y. Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications. Mar. Drugs2024, 22, 126.
Fernández, S.; Arnáiz, V.; Rufo, D.; Arroyo, Y. Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications. Mar. Drugs 2024, 22, 126.
Abstract
Indole is a versatile pharmacophore widely distributed in bioactive natural products. This privileged scaffold has been found in a variety of molecules isolated from marine organisms such as algae and sponges. Among these, indole alkaloids represent one of the biggest, most promising family of compounds, having shown a wide range of pharmacological properties, including anti-inflammatory, antiviral and anticancer activities. The aim of this review is to show the current scenario of marine indole alkaloid derivatives, covering not only the most common chemical structures, but also new synthetic routes developed during the last years as well as promising therapeutic applications.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
