Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus

Shengyuan Xu
,
Michael Hultström
ORCID logo ,
Anders Larsson
ORCID logo ,
Miklos Lipcsey
,
Cecilia Lindskog
,
Sara Bülow
,
Robert Frithiof
,
Per Venge
*
Version 1 : Received: 9 February 2024 / Approved: 13 February 2024 / Online: 13 February 2024 (11:45:22 CET)

A peer-reviewed article of this Preprint also exists.

Xu, S.; Hultström, M.; Larsson, A.; Lipcsey, M.; Lindskog, C.; Bülow, S.; Frithiof, R.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus. J. Clin. Med. 2024, 13, 2540. Xu, S.; Hultström, M.; Larsson, A.; Lipcsey, M.; Lindskog, C.; Bülow, S.; Frithiof, R.; Venge, P. The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus. J. Clin. Med. 2024, 13, 2540.

Abstract

The human phospholipase B-II precursor (HPLBII-P) was originally purified from white blood cells but is also found in other cellular structures such as kidney glomeruli and tubuli. The objective of this report was to investigate the relationship of HPLBII-P in urine to acute kidney injury in patients with COVID-19 Methods Urine was collected at admission from 132 COVID-19 patients admitted to the intensive care units (ICU) because of respiratory failure. HPLBII-P was measured by a sensitive ELISA. For comparison, HNL was measured in urine, by the ELISA configured with mabs 763/8F, as a sign of tubular affection in addition to routine biomarkers of kidney disease Results Overall, the concentrations of urinary HPLBII-P were almost 3-fold higher in COVID-19 patients as compared to healthy controls (p

Keywords

Kidney; Diabetes; COVID-19; Urine Biomarkers

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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