Lwigale, F.; Kibombo, D.; Kasango, S.D.; Tabajjwa, D.; Kungu, J.; Kalule, J.B.; Otita, M.; Kakooza, F.; Nabukenya, I.; Mayito, J.; Rwego, I.B. Prevalence, Resistance Profiles and Factors Associated with Skin and Soft-Tissue Infections at Jinja Regional Referral Hospital: A Retrospective Study. Preprints2024, 2024020237. https://doi.org/10.20944/preprints202402.0237.v1
APA Style
Lwigale, F., Kibombo, D., Kasango, S.D., Tabajjwa, D., Kungu, J., Kalule, J.B., Otita, M., Kakooza, F., Nabukenya, I., Mayito, J., & Rwego, I.B. (2024). Prevalence, Resistance Profiles and Factors Associated with Skin and Soft-Tissue Infections at Jinja Regional Referral Hospital: A Retrospective Study. Preprints. https://doi.org/10.20944/preprints202402.0237.v1
Chicago/Turabian Style
Lwigale, F., Jonathan Mayito and Innocent B. Rwego. 2024 "Prevalence, Resistance Profiles and Factors Associated with Skin and Soft-Tissue Infections at Jinja Regional Referral Hospital: A Retrospective Study" Preprints. https://doi.org/10.20944/preprints202402.0237.v1
Abstract
Skin and soft-tissue infections (SSTI) are common cases of hospital-acquired infections with aetiologic agents exhibiting antimicrobial resistance (AMR). We determined the prevalence, proportion of laboratory-investigated cases, AMR-profiles, and factors associated with SSTI and multi-drug resistance (MDR). This study was based on archived data of patients suspected of SSTI from 2019-2021 at Jinja Regional Referral Hospital. The analysis involved 268 randomly selected patient reports. Prevalence of SSTI was 66.4%. Laboratory-investigated cases were 14.11%. Staphylococcus aureus (n=51) was the most isolated organism. MDR pathogens explained 47% of infections. Methicillin-resistant S. aureus was up to 44%. In addition, 61% of Gram-negatives had the potential to produce extended-spectrum beta-lactamases, while 27% were non-susceptible to carbapenems. Ward of admission was significantly associated with infection (aPR=1.78, 95% CI: 1.003-3.18, p-value=0.04). Age category (19-35) was an independent predictor for MDR infections (aPR=2.30, 95%CI:1.02-5.23, p-value=0.04). The prevalence is relatively high with MDR pathogens responsible for almost half of the infections. Routine use of culture and sensitivity testing should be done for proper infection management. Gentamicin and ciprofloxacin can be considered for empirical management of emergency SSTI suspected of S. aureus. Recognizing SSTI under the Global Antimicrobial resistance Surveillance System would lead to improved preparedness and response to AMR.
Keywords
skin and soft-tissue infections; antimicrobial resistance; multidrug-resistance; hospital-acquired infections; global antimicrobial resistance surveillance system
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
