Senan, A.M.; Muhammed, M.T.; Akkoc, S.; Alhag, S.K.; A.Al-Shahari, E.; Al-Shuraym, L.A.; Alsudays, I.M.; AKTAŞ, A.H. Small Molecules of Lactoferrin Modification by Ionic Liquids Against SARS-CoV-2: Molecular Docking Enhanced the Results. Preprints2024, 2024020221. https://doi.org/10.20944/preprints202402.0221.v1
APA Style
Senan, A.M., Muhammed, M.T., Akkoc, S., Alhag, S.K., A.Al-Shahari, E., Al-Shuraym, L.A., Alsudays, I.M., & AKTAŞ, A.H. (2024). Small Molecules of Lactoferrin Modification by Ionic Liquids Against SARS-CoV-2: Molecular Docking Enhanced the Results. Preprints. https://doi.org/10.20944/preprints202402.0221.v1
Chicago/Turabian Style
Senan, A.M., Ibtisam M. Alsudays and Ahmet Hakan AKTAŞ. 2024 "Small Molecules of Lactoferrin Modification by Ionic Liquids Against SARS-CoV-2: Molecular Docking Enhanced the Results" Preprints. https://doi.org/10.20944/preprints202402.0221.v1
Abstract
Ionic liquid MIE-NH2 displays a new role of development of modification of glycoproteins of lactoferrin through a reductive amination mechanism to synthesize versatile pharmaceuticals. This work introduces a new strategy of modification of Lactoferrin by using methylimidazolium N-ethylamine, this ionic liquid MIE-NH2 linked to N-glycans in Lactoferrin derivatives. Using UPLC/ESI-QTOF and MALDI-TOF mass spectrometry to perform and detect the modifying of ionic liquid-linked glycoproteins. Relevantly, modifying the lactoferrin by MIE-H2 as a small molecule of ion liquid lactoferrin (IL-Lf), which could be a potential antiviral drug and it is achieved by inhibiting various targets. The probability of the lactoferrin modified as a small IL-Lf-molecule to inhibit any of these targets was investigated to find out its potency as a SARS-CoV-2 inhibitor. Molecular docking disclosed the activity of modifying glycoproteins - small IL-Lf-molecules containing amino groups and interaction with targeted Mpro, RdRp, TMPRSS2, and PLpro. Clinically, this study shows the a volubility to provide small IL-Lf-molecules as significantly important drugs that target main protease (Mpro), RNA dependent RNA polymerase (RdRp), transmembrane protease serine 2 (TMPRSS2), and Papain-like protease (PLpro).
Keywords
ionic liquid; infections; lactoferrin; N-glycans; mass spectrophotometry
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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