Unraveling the Mechanisms of Intestinal Insufficiency in Acute Peritonitis: A Comprehensive Overview

Cristina Serban; Alexandra Toma; Bianca Constantin; George Tocu; Iulia Tudorascu; Daniela Mihalache; Flavius Bulgaru; Raul Mihailov; Constantin Trus; Constantin Popazu; Dragoș Voicu

doi:10.20944/preprints202402.0184.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 2 February 2024 / Approved: 2 February 2024 / Online: 4 February 2024 (17:13:30 CET)

Acute peritonitis is a severe complication of abdominal surgery with a high mortality rate. Intes-tinal insufficiency syndrome (IIS) is a key factor in the progression of peritonitis, contributing significantly to morbidity and mortality. The most characteristic and rapid manifestation of IIS is the development of intestinal paresis. Intestinal paresis is a condition characterized by inhibi-tion of intestinal motility, with the inability to evacuate intestinal contents. Intestinal paresis is caused by a cascade of neuroreflex and humoral reactions that lead to severe microcirculatory and metabolic disturbances. In the absence of adequate treatment, IIS can progress to enteritis, a state of complete intestinal insufficiency, with the inability to absorb nutrients and water.

intestinal insufficiency syndrome; intestinal paresis; peritonitis

Medicine and Pharmacology, Surgery

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Unraveling the Mechanisms of Intestinal Insufficiency in Acute Peritonitis: A Comprehensive Overview

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