Feng, Y.; Zhang, H.; Shao, J.; Du, C.; Zhou, X.; Guo, X.; Wang, Y. Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging. Biology2024, 13, 153.
Feng, Y.; Zhang, H.; Shao, J.; Du, C.; Zhou, X.; Guo, X.; Wang, Y. Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging. Biology 2024, 13, 153.
Feng, Y.; Zhang, H.; Shao, J.; Du, C.; Zhou, X.; Guo, X.; Wang, Y. Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging. Biology2024, 13, 153.
Feng, Y.; Zhang, H.; Shao, J.; Du, C.; Zhou, X.; Guo, X.; Wang, Y. Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging. Biology 2024, 13, 153.
Abstract
Tumor immunotherapy represented by immune target blocking and chimeric antigen receptor cell therapy has developed rapidly. Among them, Natural Killer Cell (NK) is gradually becoming another preferred immunotherapy method after T cell immunotherapy because of its unique killing effect in innate immunity and adaptive immunity. Although NK cell therapy has achieved promising results in clinical trials, there are still some problems, such as low efficacy in solid tumors, insufficient penetration of NK cells and high cost of treatment. Nanomaterials are expected to be an excellent tool to improve the anti-tumor immune response of NK cells due to their advantages such as chemical specificity, biocompatibility and simple synthesis. Nanomaterials can enhance the cytotoxicity of NK cells, participate in the modification and noninvasive cell-tracking patterns of NK cells，and mediate their homing and infiltration, and thus significantly improve the efficiency of NK cell immunotherapy. In this review, we will briefly introduce the methods and mechanisms of tumor immunotherapy, emphasize the research progress of NK cell-based immunotherapy and imaging, and finally summarize the direction and research progress of nanomaterials in NK cell-based immunotherapy.
Keywords
NK cell immunotherapy; Nanomaterials; Tumor immunotherapy; Target Block; Drug Carrier
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
