Newland, V.; Jantzie, L.L.; Blazer-Yost, B.L. Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options. Physiologia2024, 4, 182-201.
Newland, V.; Jantzie, L.L.; Blazer-Yost, B.L. Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options. Physiologia 2024, 4, 182-201.
Newland, V.; Jantzie, L.L.; Blazer-Yost, B.L. Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options. Physiologia2024, 4, 182-201.
Newland, V.; Jantzie, L.L.; Blazer-Yost, B.L. Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options. Physiologia 2024, 4, 182-201.
Abstract
Hydrocephalus is caused by an overproduction of cerebrospinal fluid (CSF), a blockage of fluid circulation, or improper reabsorption. CSF accumulation in the brain’s ventricles causes ventriculomegaly and brain cell damage. Hydrocephalus can be caused by brain trauma, hemorrhage, infection, tumors, or genetic mutations. Currently, there is no cure for hydrocephalus. Treatments like shunting and endoscopic third ventriculostomies are used, but unfortunately, these techniques require brain surgery and have high failure rates. To advance the development of hydrocephalus treatments, physiologically relevant pre-clinical models are crucial. This review covers some of the current animal and cell culture methods used to study hydrocephalus. The choroid plexus epithelium (CPe) is thought to be the major producer of CSF in the brain. It is a polarized epithelium that regulates ion and water movement from a fenestrated capillary exudate to the ventricles. Despite decades of research, control of electrolyte movement in the CPe is still not fully understood. This review discusses important transporters on the CPe and how some of these could be potential targets for hydrocephalus treatment.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
