Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents

Marioara Avram; Catalin Marculescu; Petruta Preda; Eugen Chiriac; Tiberiu Burinaru; Cătălin Pârvulescu; Oana Brincoveanu; Andrei Avram

doi:10.20944/preprints202401.1946.v1

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preprints.org > chemistry and materials science > electrochemistry > doi: 10.20944/preprints202401.1946.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents

^* ,

Version 1 : Received: 27 January 2024 / Approved: 28 January 2024 / Online: 29 January 2024 (04:21:04 CET)

How to cite: Avram, M.; Marculescu, C.; Preda, P.; Chiriac, E.; Burinaru, T.; Pârvulescu, C.; Brincoveanu, O.; Avram, A. Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents. Preprints 2024, 2024011946. https://doi.org/10.20944/preprints202401.1946.v1 Avram, M.; Marculescu, C.; Preda, P.; Chiriac, E.; Burinaru, T.; Pârvulescu, C.; Brincoveanu, O.; Avram, A. Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents. Preprints 2024, 2024011946. https://doi.org/10.20944/preprints202401.1946.v1

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MDPI and ACS Style

Avram, M.; Marculescu, C.; Preda, P.; Chiriac, E.; Burinaru, T.; Pârvulescu, C.; Brincoveanu, O.; Avram, A. Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents. Preprints 2024, 2024011946. https://doi.org/10.20944/preprints202401.1946.v1

APA Style

Avram, M., Marculescu, C., Preda, P., Chiriac, E., Burinaru, T., Pârvulescu, C., Brincoveanu, O., & Avram, A. (2024). Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents. Preprints. https://doi.org/10.20944/preprints202401.1946.v1

Chicago/Turabian Style

Avram, M., Oana Brincoveanu and Andrei Avram. 2024 "Vertical Graphene-Based Electrochemical Biosensor for Detection of Specific Chemotherapeutic Agents" Preprints. https://doi.org/10.20944/preprints202401.1946.v1

Abstract

This study is part of an extended investigation into the quantitative detection of therapeutic molecules with antineoplastic properties, specifically focusing on bleomycin. The objective is to minimize adverse effects while maximizing therapeutic effectiveness. We are presenting the results for bleomycin detection, in terms of cyclic voltammetry and electrochemical impedance spectroscopy. We are continuing an approach we have recently started, of an electrochemical biosensor based on graphene, which is evidenced to be a revolutionary nanomaterial. The vertical graphene biosensor exhibited improved sensitivity, faster response, faster occurrence of the chemical reactions, and higher electrode surface conductivity, than the classical gold IDE sensor. The construction of the electrochemical sensor involved growing vertically aligned graphene nanosheets on the conductive surface of interdigitated electrodes. The results for bleomycin detection emphasized that a simpler surface modification method proved to be more efficient.

Keywords

vertical graphene; electrochemical biosensor; interdigitated electrodes; bleomycin detection

Subject

Chemistry and Materials Science, Electrochemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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