Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Whipple Disease Presenting as Isolated Transverse Myelitis in a Girl with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with Literature Review

Carolina Saffioti
ORCID logo ,
Marta Nebiolo
,
Roberta Caorsi
,
Alessio Mesini
ORCID logo ,
Mariasavina Severino
ORCID logo ,
Giacomo Brisca
* ,
Elio Castagnola
ORCID logo ,
Marco Gattorno
ORCID logo
Version 1 : Received: 26 January 2024 / Approved: 26 January 2024 / Online: 26 January 2024 (17:39:09 CET)

A peer-reviewed article of this Preprint also exists.

Saffioti, C.; Nebiolo, M.; Caorsi, R.; Mesini, A.; Severino, M.; Brisca, G.; Castagnola, E.; Gattorno, M. Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review. Infect. Dis. Rep. 2024, 16, 269-280. Saffioti, C.; Nebiolo, M.; Caorsi, R.; Mesini, A.; Severino, M.; Brisca, G.; Castagnola, E.; Gattorno, M. Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review. Infect. Dis. Rep. 2024, 16, 269-280.

Abstract

we describe an atypical case of Whipple disease involving exclusively the spinal cord in an adolescent receiving immunosuppressive therapy for systemic lupus erythematosus. The diagnosis was particularly difficult since lupus and Whipple disease can present similar clinical features and the patient’s prolonged contact with sewage was initially not mentioned. A literature review of the clinical, imaging, diagnostic, and therapeutic challenges of Whipple disease is also performed.

Keywords

Tropheryma whipplei, Whipple disease; Systemic Lupus erythematosus; immunosuppressive therapy; neuroimaging

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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