Rullo, V.; Castellaneta, F.; D’Antonio, S.; De Rosa, A.; Grieco, M.P.; Fabrizio, T. Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions. Cancers2024, 16, 1295.
Rullo, V.; Castellaneta, F.; D’Antonio, S.; De Rosa, A.; Grieco, M.P.; Fabrizio, T. Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions. Cancers 2024, 16, 1295.
Rullo, V.; Castellaneta, F.; D’Antonio, S.; De Rosa, A.; Grieco, M.P.; Fabrizio, T. Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions. Cancers2024, 16, 1295.
Rullo, V.; Castellaneta, F.; D’Antonio, S.; De Rosa, A.; Grieco, M.P.; Fabrizio, T. Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions. Cancers 2024, 16, 1295.
Abstract
Electrochemotherapy (ECT) is one of the newest therapeutic strategies employed as medical procedure for skin neoplasms’ treatment, especially for Classic Kaposi’s Sarcoma (CKS). The aim of this study was to demonstrate ECT clinical response and local control of CKS disease. Primary endpoint was to value the worth and efficacy of this local therapy in CKS skin lesions’ treatment. Nineteen CKS patients were enrolled, 14 males and 5 females with median age at diagnosis of 72. Complete response (CR) has been gained in 12 patients after first ECT attempt, meanwhile 3 and 4 out of 19 patients obtained a Partial response (PR), so that they underwent to a second and a third ECT treatment, each other. Clinical response was evaluated during all the time of the follow-up, which ranged between 3 months and 4 years with a median of 18 months. CKS skin lesions control still represents a challenge for surgeons and oncologists. Nevertheless, according to this and other authors’ recent experiences, ECT could be considered the gold standard strategy for early-stage patients, but at the same time it could be considered as a valid option in controlling Kaposi’s Sarcoma locally advanced lesions.
Public Health and Healthcare, Public Health and Health Services
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