Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of Hospital Antimicrobial Stewardship Programs: Process, Implementation, Impact and Outcomes. Review of Systematic Reviews

Version 1 : Received: 24 January 2024 / Approved: 24 January 2024 / Online: 24 January 2024 (14:21:05 CET)

A peer-reviewed article of this Preprint also exists.

Abdel Hadi, H.; Eltayeb, F.; Al Balushi, S.; Daghfal, J.; Ahmed, F.; Mateus, C. Evaluation of Hospital Antimicrobial Stewardship Programs: Implementation, Process, Impact, and Outcomes, Review of Systematic Reviews. Antibiotics 2024, 13, 253. Abdel Hadi, H.; Eltayeb, F.; Al Balushi, S.; Daghfal, J.; Ahmed, F.; Mateus, C. Evaluation of Hospital Antimicrobial Stewardship Programs: Implementation, Process, Impact, and Outcomes, Review of Systematic Reviews. Antibiotics 2024, 13, 253.

Abstract

Background: Antimicrobial Stewardship Programs (ASP) were introduced in healthcare as a public health priority to promote appropriate prescribing of antimicrobials, reduce antimicrobials adverse events as well as control challenges of antimicrobial resistance. To deliver aimed outcome objectives, ASPs involve multiple implementation measures. A review of systematic review was conducted to evaluate ASPs process and outcome measures. Guided by PRISMA frames, published systematic reviews (SR) focusing on ASPs restricted to secondary healthcare were evaluated over the past 10 years by examining major and primary databases involving all age groups. Out of 265 identified SR studies, 63 met inclusion criteria, the majority were conducted in European and North American regions. All age groups were examined in the studies but mainly conducted in adults when compared to children and infants . Both ASPs process and outcomes measures were examined equally and simultaneously through 25 different concepts, dominated by efficacy , antimicrobial resistance , and economic impact while information technology as well as role of pharmacy and behavioural factors were equally examined . The main broad conclusions from the review , that across the globe, ASPs demonstrated effectiveness, proved efficacy, and confirmed efficiency while focused evaluation advocate that developed countries should target medium and small sized hospitals while developing countries should continue rolling ASPs in their healthcare facilities . Additionally , the future of ASPs should focus on embracing evolving information technology to bridge gaps in knowledge, alter attitude and enhance decision making .

Keywords

Antimicrobial Stewardship (ASP / AMSP), Antimicrobial consumption, Antimicrobial Resistance

Subject

Public Health and Healthcare, Public Health and Health Services

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