Version 1
: Received: 22 January 2024 / Approved: 23 January 2024 / Online: 23 January 2024 (07:54:00 CET)
How to cite:
Sun, Y.; Wang, L. Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge Technology. Preprints2024, 2024011662. https://doi.org/10.20944/preprints202401.1662.v1
Sun, Y.; Wang, L. Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge Technology. Preprints 2024, 2024011662. https://doi.org/10.20944/preprints202401.1662.v1
Sun, Y.; Wang, L. Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge Technology. Preprints2024, 2024011662. https://doi.org/10.20944/preprints202401.1662.v1
APA Style
Sun, Y., & Wang, L. (2024). Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge Technology. Preprints. https://doi.org/10.20944/preprints202401.1662.v1
Chicago/Turabian Style
Sun, Y. and Lingyun Wang. 2024 "Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge Technology" Preprints. https://doi.org/10.20944/preprints202401.1662.v1
Abstract
With the first case of human immunodeficiency virus (HIV) infection confirmed in US in 1981, the efforts of discovering anti-HIV therapeutics have been continued ever since. Ten years later, the first HIV drug zidovudine (AZT) was developed to inhibit HIV reverse transcriptase. At meantime, scientists were enlightened to discover new drugs of different targets acting on HIV integrase, protease, and host receptors. The advent of combination antiretroviral therapy (cART) is completely a game changer, with high efficiency in suppressing viremia for people with HIV (PWH) by controlling the viral load below the detectable level. On the bright side, the ART treatment has made HIV a chronic infection rather than a fatal disease. However, it cannot eradicate integrated HIV DNA from the host cells, thus the latent viral reservoir has become a lifelong threaten. In this review, we first discuss the scientific history of conventional HIV drug discovery, with more and more anti-HIV agents have been developed to solve drug resistant issue and relieve the side effect. As a complementary therapy, advanced gene editing technologies have been applied to excise HIV provirus from host genome. Within four decades, novel research conducted on HIV treatment and their contributions to eliminate HIV have been altogether summarized in our review.
Keywords
HIV; cART; eene editing; CRISPR
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
