Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Vaccination and Patient Status of Long COVID-19 Hospitalized Patients: A Cohort Observational Study

Version 1 : Received: 22 January 2024 / Approved: 23 January 2024 / Online: 23 January 2024 (07:14:37 CET)

How to cite: Kirbiš, S.; Sobotkiewicz, N.; Schaubach, B.A.; Završnik, J.; Kokol, P.; Završnik, M.; Vošner, H.B. Vaccination and Patient Status of Long COVID-19 Hospitalized Patients: A Cohort Observational Study. Preprints 2024, 2024011613. https://doi.org/10.20944/preprints202401.1613.v1 Kirbiš, S.; Sobotkiewicz, N.; Schaubach, B.A.; Završnik, J.; Kokol, P.; Završnik, M.; Vošner, H.B. Vaccination and Patient Status of Long COVID-19 Hospitalized Patients: A Cohort Observational Study. Preprints 2024, 2024011613. https://doi.org/10.20944/preprints202401.1613.v1

Abstract

Long COVID–19 syndrome is another vicious feature of COVID-19 infection, the mechanism remains unidentified. Several observational studies suggest that vaccinations might have protective and therapeutic effect on long COVID-19 and our study aimed to assess the influence of vaccination on COVID-19 patients. We performed an observational cohort study from October 2020 to July 2022, which included 503 patients (291 males and 212 females) with a median age of 65. They were hospitalized due to COVID-19 pneumonia and had persistent symptoms (after 1 month of COVID-19 infection. The clinical and demographic data including vaccination status collected during hospitalization and regular visits at the Community Healthcare Center dr. Adolf Drolc Maribor were analyzed. More non-vaccinated patients acquired long COVID-19 than vaccinated. Patients with type 2 diabetes suffered from long COVID-19 in a smaller percentage than patients without diabetes. Gender, inhalational therapy due to chronic pulmonary disease and the number of complications have significantly influenced long COVID-19 development and the mostly vaccinated patients were older and with asthma/COPD. Our study confirmed that vaccination is a safe and effective measure to prevent the severe progression of acute disease and to lower the incidence of developing long COVID.

Keywords

long -COVID-19 syndrome; vaccination; comorbidities; COVID-19 pneumonia; observational

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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