Barco, G.; Khalid, Z.; Pulliero, A.; Angelinetta, C.; Prati, U.; Izzotti, A. Indoor Inactivation of SARS-CoV-2 Virus by Liquid Hyperoxygen. Pathogens2024, 13, 244.
Barco, G.; Khalid, Z.; Pulliero, A.; Angelinetta, C.; Prati, U.; Izzotti, A. Indoor Inactivation of SARS-CoV-2 Virus by Liquid Hyperoxygen. Pathogens 2024, 13, 244.
Barco, G.; Khalid, Z.; Pulliero, A.; Angelinetta, C.; Prati, U.; Izzotti, A. Indoor Inactivation of SARS-CoV-2 Virus by Liquid Hyperoxygen. Pathogens2024, 13, 244.
Barco, G.; Khalid, Z.; Pulliero, A.; Angelinetta, C.; Prati, U.; Izzotti, A. Indoor Inactivation of SARS-CoV-2 Virus by Liquid Hyperoxygen. Pathogens 2024, 13, 244.
Abstract
The possible future emergence of new SARS-CoV-2 virus variants pushes the development of new chemoprophylaxis protocols complementary to the unspecific and specific immune-prophylaxis measures currently used. The SARS-CoV-2 virus is particularly sensitive to oxidation due to the relevant positive electrical charge of its spike protein used as a ligand for target cells. The present study evaluated the safety and efficacy of a new oxidant preparation, liquid hyperoxygen (IOL), to neutralize the SARS-CoV-2 virus. IOL was incubated with throat swabs containing a human wild-type virus. The samples were then incubated with cells expressing the ACE2 receptor and therefore very sensitive to SARS-CoV-2 infection. The ability to neutralize SARS-CoV-2 was determined by assessing the amount of viral nucleic acid inside cells by PCR. The results obtained indicate that IOL, even at considerable dilutions, is capable, after incubation times of less than 30 min and even equal to 5 min, to completely inhibit SARS-CoV-2 infection. This inhibitory effect has been shown to be due to the oxidizing capacity of the IOL. This oxidizing capacity is exerted towards the virus but does not damage eukaryotic cells either in the in vitro or in the in vivo skin model. Obtained results indicate that the use of IOL, a hydrophilic liquid mixture saturated with highly reactive oxygen and nitrogen species, is a new powerful, safe, and effective tool for preventing possible future outbreaks of COVID-19 disease.
Public Health and Healthcare, Public, Environmental and Occupational Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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