Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A gadolinium(III) Complex Based on Pyridoxine Molecule with Single-Ion Magnet and Magnetic Resonance Imaging Properties

Marta Orts-Arroyo
ORCID logo ,
Amadeo Ten-Esteve
,
Sonia Ginés-Cárdenas
,
Leonor Cerda-Alberich
ORCID logo ,
Luis Marti-Bonmati
,
José Martínez-Lillo
* ORCID logo
Version 1 : Received: 17 January 2024 / Approved: 17 January 2024 / Online: 17 January 2024 (11:10:55 CET)

A peer-reviewed article of this Preprint also exists.

Orts-Arroyo, M.; Ten-Esteve, A.; Ginés-Cárdenas, S.; Cerdá-Alberich, L.; Martí-Bonmatí, L.; Martínez-Lillo, J. A Gadolinium(III) Complex Based on Pyridoxine Molecule with Single-Ion Magnet and Magnetic Resonance Imaging Properties. Int. J. Mol. Sci. 2024, 25, 2112. Orts-Arroyo, M.; Ten-Esteve, A.; Ginés-Cárdenas, S.; Cerdá-Alberich, L.; Martí-Bonmatí, L.; Martínez-Lillo, J. A Gadolinium(III) Complex Based on Pyridoxine Molecule with Single-Ion Magnet and Magnetic Resonance Imaging Properties. Int. J. Mol. Sci. 2024, 25, 2112.

Abstract

Pyridoxine is a versatile molecule that forms part of the family of B vitamins. It is used to treat and prevent vitamin B6 deficiency and certain type of metabolic disorders. Besides, pyridoxine molecule has been investigated as a suitable ligand toward metal ions. Nevertheless, the study of the magnetic properties of metal complexes containing lanthanide(III) ions and this biomolecule has been unexplored. We have synthesized and characterized a novel pyridoxine-based GdIII complex of formula [Gd(III)(pyr)2(H2O)4]Cl3 • 2 H2O (1) [pyr = pyridoxine]. 1 crystallizes in the triclinic system with space group Pī. In its crystal packing, the cationic [Gd(pyr)2(H2O)4]3+ entities are linked each other through H-bonding interactions involving non-coordinating water molecules and chloride anions. In addition, Hirshfeld surfaces of 1 were calculated to further investigate their intermolecular interactions in the crystal lattice. The study of the magnetic properties of 1 through ac magnetic susceptibility measurements reveals the occurrence of slow relaxation of magnetization in this mononuclear Gd(III) complex, this fact indicating an unusual single-ion magnet (SIM) behavior. We have also studied the relaxometric properties of 1, as a potential contrast agent for high-field MR imaging, from solutions of 1 prepared in physiological serum (0.0 - 3.2 mM range) and measured at 3 T on a clinical MR scanner. The relaxivity values obtained for 1 are larger than those of some commercial MR imaging contrast agents based on mononuclear Gd(III) systems

Keywords

gadolinium; vitamin B6; single-ion magnet; magnetic resonance; contrast agent; relaxivity

Subject

Chemistry and Materials Science, Inorganic and Nuclear Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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